SkyRx vs Vytora Health
An in-depth comparison of two leading GLP-1 Providers
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SkyRx
Best for: shoppers wanting all-inclusive compounded semaglutide with supplies included
Visit SkyRx →
Vytora Health
Best for: compounded or brand-name GLP-1 with named pharmacy partners, 50 states
Visit Vytora Health →SkyRx and Vytora Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Vytora Health starts lower at $150/mo versus $199/mo, and Vytora Health edges ahead overall (8.4 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
SkyRx
199/mo on a 12-month prepaid subscription; includes med, supplies, visit, shipping
Vytora Health
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What’s included
SkyRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Vytora Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
SkyRx
6.7/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | SkyRx | Vytora Health |
|---|---|---|
| Starting Price | $199/mo | ✓$150/mo |
| Features | 6 features | ✓8 features |
| States Available | Not disclosed | 51 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About SkyRx
SkyRx (sky-rx.co) is a US telehealth weight-loss program offering compounded semaglutide as an injection or oral drops, with compounded tirzepatide listed as coming soon. Pricing starts at 199 dollars per month on a 12-month subscription paid upfront, and the single monthly price bundles medication, supplies, doctor visit and shipping with no insurance needed. Medication is dispensed by FDA-registered 503B compounding pharmacies. GLP-1s are not yet available in all 50 states. Support is by phone at 855-759-7979 and email; the company is based in Draper, Utah.
Read our full SkyRx review →About Vytora Health
Vytora Health is a 50-state-plus-DC telehealth platform offering compounded semaglutide and tirzepatide alongside brand-name Mounjaro and Zepbound, plus NAD+ and sermorelin peptides. It names its pharmacy partners publicly — Vials Pharmacy and Greenwich Biosciences — and discloses its operating physician group, uncommon transparency for the category. Compounded semaglutide runs $180/mo ($150 on a 3-month bundle) and tirzepatide $249/mo ($200 bundled).
Read our full Vytora Health review →Pros & Cons
SkyRx
What we like
- All-inclusive 199 dollars per month covers medication, supplies, doctor visit and shipping
- Offers both injectable and oral semaglutide, dispensed by FDA-registered 503B pharmacies
- Same-day shipping for orders before 2pm ET in temperature-controlled packaging
Watch-outs
- 199 dollars pricing requires a 12-month subscription paid upfront
- Tirzepatide only listed as coming soon
- GLP-1s not yet available in all 50 states; specific states not listed
Vytora Health
What we like
- All 50 states plus DC, with per-state video-vs-audio compliance disclosed
- Both compounded and brand-name options on one platform — uncommon
- LegitScript Approved and HIPAA compliant
- Pharmacy partners named publicly: Vials Pharmacy (TX) and Greenwich Biosciences
- Operating entity disclosed: Wasef Health, PC (Pinellas Park, FL)
- Competitive monthly pricing ($180 sema / $249 tirz) plus a 3-month bundle saving 17%
- Brand-name Mounjaro and Zepbound available at $1,399/mo for FDA-approved options
Watch-outs
- Brand-name Mounjaro/Zepbound at $1,399/mo is near retail — insured patients may do better via LillyDirect Self Pay ($449-$699/mo)
- Compounded tirzepatide at $249/mo is mid-market, above the $149-199 floor
- Dose tiers aren't broken out — 'all doses included' means low-dose patients pay the same as high-dose
- Initial consultation cost not shown on the public pricing page
- Limited per-prescriber state licensure detail
Our Verdict
Vytora Health edges out SkyRx with a higher overall score of 8.4/10 and is particularly strong for compounded or brand-name GLP-1 with named pharmacy partners, 50 states. SkyRx remains a solid alternative, especially if you're looking for shoppers wanting all-inclusive compounded semaglutide with supplies included.
Choose SkyRx if…
You want shoppers wanting all-inclusive compounded semaglutide with supplies included and a starting price around $199/mo.
Choose Vytora Health if…
You want compounded or brand-name GLP-1 with named pharmacy partners, 50 states and a starting price around $150/mo.
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Telos Rx
Needle-free and microdosed compounded GLP-1 options with lab-monitored care
From $49/mo
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Listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →SkyRx vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.