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PCOS Sisters vs NewSelf

An in-depth comparison of two leading GLP-1 Providers

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By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed

PCOS Sisters

7.2
★★★3.6/5

Best for: women with pcos seeking glp-1 weight and metabolic care

Visit PCOS Sisters
VS
NewSelf logo

NewSelf

8.3
★★★★4.2/5

Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency

Visit NewSelf

PCOS Sisters and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $150/mo, and NewSelf edges ahead overall (8.3 vs 7.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.

Pricing

PCOS Sisters

All doses (flat)Compounded
$150/mo
semaglutide

GLP-1 management fee, membership required; billed monthly

All doses (flat)Compounded
$150/mo
tirzepatide

Same 150/mo GLP-1 management fee; tirzepatide referenced in program

NewSelf

Semaglutide+ (best price)Compounded
$100/mo
semaglutide

All dosages same price

Semaglutide+ (regular)Compounded
$135/mo
semaglutide
Tirzepatide+ (best price)Compounded
$144/mo
tirzepatide

All dosages same price

Tirzepatide+ (regular)Compounded
$225/mo
tirzepatide

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What’s included

PCOS Sisters

What the monthly price covers

Medication

Included

Provider visits

Included

Shipping

Included

Lab work

Not disclosed

Coaching

Not disclosed

NewSelf

What the monthly price covers

Medication

Included

Provider visits

Included

Shipping

Included

Lab work

Not disclosed

Coaching

Not disclosed

Score breakdown

Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.

PCOS Sisters

7.2/10

Overall

NewSelf

8.3/10

Value25%

7.5A
vs
B
9.0

Effectiveness25%

7.5A
vs
B
8.0

User Experience15%

7.0A
vs
B
8.0

Trust & Safety15%

7.0A
vs
B
8.3

Accessibility10%

6.5A
vs
B
8.5

Support10%

7.0A
vs
B
7.9

Features & Coverage

FeaturePCOS SistersNewSelf
Starting Price$150/mo$100/mo
Features6 features6 features
States Available1249
Compounded✓ Yes✓ Yes
Brand Name
FSA/HSA Accepted
FDA WarningsNoneNone

About PCOS Sisters

PCOS Sisters is a women's telehealth clinic focused on polycystic ovary syndrome that offers a GLP-1 weight and metabolic management program for 150 dollars per month with membership required. Providers prescribe semaglutide (the active ingredient in Wegovy and Ozempic), tirzepatide, and oral GLP-1 options, integrated with a PCOS-focused metabolic program and fitness app. Care is available across 12 states and prescriptions are filled through named partner pharmacies including Strive Pharmacy and Striker Pharmacy. Cash-pay model, no insurance.

Read our full PCOS Sisters review →

About NewSelf

NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.

Read our full NewSelf review →

Pros & Cons

PCOS Sisters

What we like

  • Dedicated PCOS specialty model with metabolic program and fitness app included
  • Transparent 150 dollars per month GLP-1 management fee
  • Names real partner pharmacies (Strive, Striker) and lists phone support

Watch-outs

  • Only 12 states served
  • Membership required on top of the medical program
  • Unclear whether pharmacy dispensing fees are separate from the 150/mo fee

NewSelf

What we like

  • Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
  • All dosages at the same price — no price escalation as dose increases
  • LegitScript certified with 503A licensed pharmacies
  • Third-party potency, sterility, and endotoxicity testing
  • 48 states + Puerto Rico coverage
  • B12/B6 + Glycine enhanced formulations
  • No membership fees

Watch-outs

  • Not available in Mississippi and Louisiana
  • Compounded only — no brand-name options
  • Site also promotes AI health optimization and longevity (broader platform)

Our Verdict

Winner: NewSelf

NewSelf edges out PCOS Sisters with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. PCOS Sisters remains a solid alternative, especially if you're looking for women with pcos seeking glp-1 weight and metabolic care.

Choose PCOS Sisters if…

You want women with pcos seeking glp-1 weight and metabolic care and a starting price around $150/mo.

Choose NewSelf if…

You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.

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8.3

Found

Mainstream telehealth GLP-1 access

7.4

Breeze Meds

Compounded GLP-1 access with named prescribers and 4-pharmacy network

7.4

Telos Rx

Needle-free and microdosed compounded GLP-1 options with lab-monitored care

PCOS Sisters vs NewSelf: FAQ

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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.