NewSelf vs Vyvron
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Vyvron
Best for: a locked founding rate from a platform that names its clinical partner and holds a real LegitScript seal
Visit Vyvron →NewSelf and Vyvron are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $179/mo, and NewSelf edges ahead overall (8.3 vs 6.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Vyvron
Founding-member rate of $149 per 4 weeks is locked for the life of the membership; the standing rate is $179. Vyvron does not state which medication this tier buys.
Founding-member rate of $199 per 4 weeks is locked for the life of the membership; the standing rate is $249. Vyvron does not state which medication this tier buys.
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Vyvron
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Vyvron
6.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Vyvron |
|---|---|---|
| Starting Price | ✓$100/mo | $179/mo |
| Features | ✓6 features | 5 features |
| States Available | 49 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Vyvron
Vyvron is a Wyoming-registered telehealth access platform for online weight-management evaluation. It is explicit that it is not a medical practice or pharmacy: clinical and pharmacy services run through OpenLoop Health and its affiliated professional entities. Membership is sold at two tiers, currently $149 and $199 per four weeks under a founding-member rate that reverts to $179 and $249, and the site carries a verified LegitScript certification. Vyvron names semaglutide and tirzepatide as possible options but never ties either drug to a published price.
Read our full Vyvron review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Vyvron
What we like
- Carries a genuine LegitScript seal (ID 50305996) that resolves on LegitScript's own asset host, with the domain named in the badge.
- Names OpenLoop Health as the clinical and pharmacy partner, and links its telehealth consent to OpenLoop directly.
- Unusually blunt disclosures: states plainly it is not a medical practice or pharmacy and that compounded drugs are not FDA-approved.
- No cancellation fees, and the founding rate is contractually locked for as long as the membership runs.
Watch-outs
- No price is tied to a medication anywhere, so you cannot tell which tier buys semaglutide and which buys tirzepatide before paying.
- Billed every four weeks, which is 13 charges a year rather than 12, so the true annual cost is a month higher than it looks.
- "100 of 100 founding spots left" appears twice on the page and does not count down, so the scarcity framing is not real.
- Registered at 30 N Gould St, Sheridan WY, a mass registered-agent address, and no state coverage list is published.
Our Verdict
NewSelf edges out Vyvron with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Vyvron remains a solid alternative, especially if you're looking for a locked founding rate from a platform that names its clinical partner and holds a real LegitScript seal.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Vyvron if…
You want a locked founding rate from a platform that names its clinical partner and holds a real LegitScript seal and a starting price around $179/mo.
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TrimRx
Best overall value
From $135/mo
Get started →Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →PeterMD
Men wanting flat-priced compounded GLP-1 with TRT or peptides
From $105/mo
Get started →NewSelf vs Vyvron: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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