NewSelf vs Vaylen
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Vaylen
Best for: GLP-1-focused care with oral and injectable options across all 50 states
Visit Vaylen →NewSelf and Vaylen are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $179/mo, and NewSelf edges ahead overall (8.3 vs 7.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Vaylen
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Vaylen
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Included
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Vaylen
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Vaylen |
|---|---|---|
| Starting Price | ✓$100/mo | $179/mo |
| Features | 6 features | ✓8 features |
| States Available | 49 | ✓50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Vaylen
Vaylen is a pure GLP-1 specialist offering compounded semaglutide ($179/mo), compounded tirzepatide ($239/mo), compounded oral GLP-1 ($259/mo), and brand-name Ozempic, Zepbound, and Wegovy. LegitScript certified. Licensed clinicians in all 50 states.
Read our full Vaylen review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Vaylen
What we like
- Pure GLP-1 specialist — not a multi-category telehealth platform
- All 50 states coverage with licensed clinicians
- Both compounded and brand-name options (Ozempic, Wegovy, Zepbound)
- Oral GLP-1 option (compounded dissolvable tablets) for needle-averse patients
- LegitScript certified
- Transparent pricing — no hidden costs, no insurance required
- Continuous coaching and lab support included
Watch-outs
- Compounded semaglutide at $179/mo is mid-range (not the cheapest)
- Brand-name options at near-retail pricing ($997-$1,086/mo)
Our Verdict
NewSelf edges out Vaylen with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Vaylen remains a solid alternative, especially if you're looking for GLP-1-focused care with oral and injectable options across all 50 states.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Vaylen if…
You want GLP-1-focused care with oral and injectable options across all 50 states and a starting price around $179/mo.
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MEDVi
Patients who want the option to switch between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Liv Body
Compounded GLP-1 paired with a muscle-preservation supplement stack
From $179/mo
Get started →DudeMeds
Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →NewSelf vs Vaylen: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.