NewSelf vs Trellis Vitality
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Trellis Vitality
Best for: body-composition tracking and flat per-dose pricing without a membership fee
Visit Trellis Vitality →NewSelf and Trellis Vitality are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $150/mo, and NewSelf edges ahead overall (8.3 vs 7.5 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Trellis Vitality
Per-month rate falls on longer plans: $150 monthly, $140 on 3 months, $133 on 6 months. All dosages cost the same.
Per-month rate falls on longer plans: $199 monthly, $189 on 3 months, $179 on 6 months. All dosages cost the same.
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Trellis Vitality
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Trellis Vitality
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Trellis Vitality |
|---|---|---|
| Starting Price | ✓$100/mo | $150/mo |
| Features | 6 features | ✓7 features |
| States Available | 49 | ✓50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Trellis Vitality
Trellis Vitality is an online longevity clinic that frames weight loss around body composition rather than scale weight. Compounded semaglutide starts at $150 a month and tirzepatide at $199, with every dose priced the same and no membership or consult fee layered on top. The programme pairs GLP-1s with at-home biomarker panels, a 90-day re-test, and muscle-preserving options such as tesamorelin and glycine formulations. Trellis is a care-coordination company; prescribing is done by the Arora Health provider network and dispensing by Houston pharmacy VialsRX.
Read our full Trellis Vitality review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Trellis Vitality
What we like
- Names both its pharmacy (VialsRX, Houston TX) and its prescribing network, with a street address and phone number for the pharmacy.
- All dosages cost the same, and there is no membership fee or consult charge on top of the monthly price.
- Frames the programme around body composition, with at-home biomarker panels and a 90-day re-test rather than scale weight alone.
- Will review labs from an existing compounded programme and recommend protocol adjustments free of charge.
Watch-outs
- Headline stats (92% biomarker improvement, $4,000 average annual saving, 3.4 weeks saved) are unsourced and cannot be checked.
- The "4.7 / 5 · 5,000+ current patients" rating names no review platform, so it cannot be verified against a public record.
- Prescribing runs through the Arora Health network, which several unrelated telehealth brands also use, so the clinical layer is not exclusive.
- Refund eligibility is decided per order rather than by a stated policy, so outcomes are discretionary.
Our Verdict
NewSelf edges out Trellis Vitality with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Trellis Vitality remains a solid alternative, especially if you're looking for body-composition tracking and flat per-dose pricing without a membership fee.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Trellis Vitality if…
You want body-composition tracking and flat per-dose pricing without a membership fee and a starting price around $150/mo.
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Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $112/mo
Get started →MEDVi
Switching between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Liv Body
Compounded GLP-1 paired with a muscle-preservation supplement stack
From $179/mo
Get started →NewSelf vs Trellis Vitality: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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