NewSelf vs Synergy Rx
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Synergy Rx
Best for: broadest drug catalog in the Lion MD white-label cluster
Visit Synergy Rx →NewSelf and Synergy Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $199/mo, and Synergy Rx is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Synergy Rx
$100 welcome credit auto-applied at checkout site-wide; free shipping
$100 above tirz median $249
MISSING as a row in providers.json pricing array (only in description text)
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 390+ providers' prices on their own sites and email you when tracked prices move.
What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Synergy Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Synergy Rx
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Synergy Rx |
|---|---|---|
| Starting Price | ✓$100/mo | $199/mo |
| Features | 6 features | 6 features |
| States Available | 49 | ✓50 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Synergy Rx
Synergy Rx (CareGLP platform, synergyrx.co) is a Wyoming-registered telehealth platform serving 50,000+ patients with compounded semaglutide ($199), tirzepatide ($349), and brand-name Ozempic ($499), Wegovy ($947), and Mounjaro ($947). Runs on the shared Lion MD clinician + 4-pharmacy network with Breeze Meds and Care Bare Rx.
Read our full Synergy Rx review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Synergy Rx
What we like
- Broad catalog: compounded sema/tirz in injection and oral dissolving tablet, plus brand Ozempic, Wegovy, and Mounjaro
- Claims 50,000+ patients as of late 2025
- Available in all 50 states, subject to state telehealth rules
- Same medical team as Breeze Meds and Care Bare Rx (Dr. Carr and Dr. Tenbrink via Lion MD)
- Four named 503A pharmacy partners (Belmar, Strive, Epiq Scripts, Casa Pharma Rx)
- LegitScript Certified
Watch-outs
- Same clinician network and pharmacies as Breeze Meds and Care Bare Rx — three brands on one underlying operation
- Mandatory individual arbitration + class-action waiver (30-day opt-out from signup)
- Consultation fees non-refundable and all prescription sales final
- Disclaims liability for third-party pharmacy medication quality
- Full active-state list requires contacting support, not published
- Correct site is synergyrx.co — synergyrx.com is an unrelated parked domain
Our Verdict
Synergy Rx is our recommended choice here, particularly for broadest drug catalog in the Lion MD white-label cluster. NewSelf is a solid alternative, especially if you want lowest-cost compounded GLP-1 with pharmacy quality transparency — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Synergy Rx if…
You want broadest drug catalog in the Lion MD white-label cluster and a starting price around $199/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $112/mo
Get started →MEDVi
Patients who want the option to switch between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Liv Body
Compounded GLP-1 paired with a muscle-preservation supplement stack
From $179/mo
Get started →NewSelf vs Synergy Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring NewSelf and Synergy Rx head-to-heads in the same category.
- NewSelf vs Amazon One Medical
- NewSelf vs Vytora Health
- NewSelf vs CoreAge Rx
- Synergy Rx vs EverSlim
- Synergy Rx vs Found
- Synergy Rx vs Elara Health and Wellness
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.