NewSelf vs Ryze Rx
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Ryze Rx
Best for: compounded GLP-1s plus a broad TRT and peptide menu on one platform
Visit Ryze Rx →NewSelf and Ryze Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $199/mo, and NewSelf edges ahead overall (8.3 vs 7.4 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Ryze Rx
Injectable Semaglutide 1 Month $199 / 3 Month Bundle $499 verified on joinryzerx.com/services/weight-loss 2026-06-19; homepage 'from $149/mo' headline not matched by catalog rows
Injectable Tirzepatide 1 Month $199 / 3 Month Bundle $799 verified on joinryzerx.com/services/weight-loss 2026-06-19
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Ryze Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Ryze Rx
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Ryze Rx |
|---|---|---|
| Starting Price | ✓$100/mo | $199/mo |
| Features | ✓6 features | 5 features |
| States Available | 49 | Not disclosed |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Ryze Rx
Ryze Rx is a prescription telehealth platform for weight loss, TRT and peptide therapy, prescribing through board-certified physicians and shipping from US-licensed compounding pharmacies. For weight loss it offers compounded injectable semaglutide and tirzepatide at $199/mo (or $499/$799 for a 3-month bundle), with physician consult and shipping included. The homepage advertises care in all 50 states.
Read our full Ryze Rx review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Ryze Rx
What we like
- Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
- Physician consultation, ongoing clinical support and discreet shipping included with each prescription
- Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
- Free shipping, 24hr prescription turnaround, FSA/HSA eligible; care advertised in all 50 states
Watch-outs
- Terms, Privacy Policy and HIPAA notice are dead links - no legal entity, refund policy or governing law disclosed
- Pharmacy partners not named - only 'US-licensed compounding pharmacies'
- Homepage advertises GLP-1s 'from $149/mo' but the catalog lists $199/mo
- On-site '4.9/5, 2,400+ reviews' is self-reported, not an independently verified rating
Our Verdict
NewSelf edges out Ryze Rx with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Ryze Rx remains a solid alternative, especially if you're looking for compounded GLP-1s plus a broad TRT and peptide menu on one platform.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Ryze Rx if…
You want compounded GLP-1s plus a broad TRT and peptide menu on one platform and a starting price around $199/mo.
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MEDVi
Patients who want the option to switch between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Liv Body
Compounded GLP-1 paired with a muscle-preservation supplement stack
From $179/mo
Get started →DudeMeds
Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →NewSelf vs Ryze Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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