MedLeanRx vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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MedLeanRx
Best for: Texas-only compounded semaglutide at $149/mo, plus brand options
Visit MedLeanRx →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →MedLeanRx and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both start around $149/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
MedLeanRx
Weekly semaglutide vial $149/mo; plans 'start at $149/month for the starting dose' — pricing may vary with medication and dosage
Needle-free daily oral semaglutide tablets, $149/mo
$269/mo standard; intro bundle: 2-month supply at 2 mg weekly for $325 (~$163/mo), Texas clients only, while supplies last
Amazon One Medical
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What’s included
MedLeanRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
MedLeanRx
7.2/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | MedLeanRx | Amazon One Medical |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | ✓8 features | 6 features |
| States Available | 1 | ✓50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About MedLeanRx
MedLeanRx is a physician-guided telehealth weight-loss clinic serving Texas only, based in Spring, TX. It prescribes compounded semaglutide as a weekly injection or daily oral tablet at $149/month and compounded tirzepatide at $269/month, plus a brand pathway for Wegovy, Zepbound, and Foundayo (orforglipron) at a $99/month fee where medication is billed separately. A 5-minute online assessment gets a 24-48 hour physician review, with free shipping and cancel-anytime plans.
Read our full MedLeanRx review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
MedLeanRx
What we like
- Compounded semaglutide $149/mo in both weekly injection and daily oral tablet form
- Brand pathway for Wegovy, Zepbound, and Foundayo (orforglipron) at a $99/mo fee plus medication cost
- Intro bundle: 2 months of compounded tirzepatide (2 mg weekly) for $325 — about $163/mo
- LegitScript seal displayed; named supervising physician (Dr. Johnson Uzor, MD)
- Free shipping, no hidden fees, and cancel-anytime plans per homepage trust chips
- 5-minute online assessment with 24-48 hour physician review — 100% online, no clinic visits
Watch-outs
- Texas only — not available in the other 49 states
- Compounded tirzepatide is $269/mo at standard pricing, above the ~$249 market median
- Strict no-refund policy: 'All sales are final' per Terms & Conditions
- Pharmacy partner not publicly named — a transparency gap for a compounding service
- Legal entity name and founding details not published on the site
- Brand-medication total cost not published — $99/mo fee plus the separate cost of medication
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out MedLeanRx with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. MedLeanRx remains a solid alternative, especially if you're looking for Texas-only compounded semaglutide at $149/mo, plus brand options.
Choose MedLeanRx if…
You want Texas-only compounded semaglutide at $149/mo, plus brand options and a starting price around $149/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →YourEra
$99 first-month entry pricing on compounded GLP-1s
From $99/mo
Get started →Gala
Compounded GLP-1/GIP combo on a yearly plan with free shipping
From $129/mo
Get started →MedLeanRx vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.