MediRX vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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MediRX
Best for: legitScript-certified compounded GLP-1 with low first-month promo pricing
Visit MediRX →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →MediRX and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both start around $149/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
MediRX
$149 to start, with $120 off a first month and as little as $70 for the first month on the 6-month plan. No insurance required. ⚠ MediRX's homepage also prints $179 for the same product in a second grid.
Amazon One Medical
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What’s included
MediRX
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
MediRX
7.3/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | MediRX | Amazon One Medical |
|---|---|---|
| Starting Price | $149/mo | $149/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | — | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About MediRX
MediRX is a telehealth weight-loss platform offering compounded GLP-1 injections — semaglutide starting at $149/month and tirzepatide starting at $199/month — plus NAD+ and a name-brand GLP-1 option. Care runs on OpenLoop Health: a licensed provider reviews your online intake and prescribes if appropriate, with fulfillment through OpenLoop's partnered U.S. licensed pharmacies. The site is LegitScript Certified and the operating entity, MediRX, Inc. of Wyoming, is disclosed, though it doesn't publish the exact states it serves.
Read our full MediRX review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
MediRX
What we like
- LegitScript Certified — a meaningful trust signal for an online pharmacy
- Named operating entity disclosed (MediRX, Inc., Wyoming)
- Care and pharmacy fulfillment run on OpenLoop Health's licensed network
- Low promotional first-month pricing — semaglutide first month as low as $70
Watch-outs
- Doesn't publish the exact states it serves; telehealth rules vary by state
- Ongoing monthly price rises after the promotional first month
- Compounded semaglutide and tirzepatide injections — limited oral options
- Specific compounding pharmacies aren't named beyond the OpenLoop network
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out MediRX with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. MediRX remains a solid alternative, especially if you're looking for legitScript-certified compounded GLP-1 with low first-month promo pricing.
Choose MediRX if…
You want legitScript-certified compounded GLP-1 with low first-month promo pricing and a starting price around $149/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
Ready to start? Vetted GLP-1 providers
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Trimi Health
Budget-conscious shoppers
From $99/mo
Get started →ShedRx
Mainstream telehealth GLP-1 access
From $149/mo
Get started →bmiMD
Mainstream telehealth GLP-1 access
From $99/mo
Get started →MediRX vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.