Knownwell vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Knownwell
Best for Patients wanting branded GLP-1s with obesity-medicine oversight and insurance optionsStarting at $349/mo
Amazon One Medical
Best for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savingsStarting at $25/mo
Side-by-Side Comparison
| Feature | Knownwell | Amazon One Medical |
|---|---|---|
| Overall Score | 7.8/10 | ✓8.7/10 |
| Starting Price | $349/mo | ✓$25/mo |
| Editorial Rating | 3.9 ★ /5 | ✓4.4 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓50 |
| Compounded | — | — |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Knownwell
Pros
- ✓Co-founded by obesity-medicine specialist Dr. Angela Fitch
- ✓Branded FDA-approved GLP-1s (Wegovy, Zepbound, Ozempic, Saxenda)
- ✓Official LillyDirect provider and Novo Wegovy-pill telehealth partner
- ✓Accepts insurance, copays as low as $25 for covered patients
- ✓Weight-inclusive care with dietitians and health coaches
- ✓Both virtual (50 states) and in-person clinic options
Cons
- ✗Specific self-pay monthly medication prices not transparently posted
- ✗In-person clinics limited to four metro areas
- ✗Branded-only focus can mean higher cost than compounded routes
Amazon One Medical
Pros
- ✓As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- ✓Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- ✓In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- ✓Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- ✓Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- ✓Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Cons
- ✗Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- ✗Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- ✗Pricing is set by manufacturer savings programs and can change at any time
- ✗No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- ✗Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- ✗Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Knownwell with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Knownwell remains a solid alternative, especially if you're looking for Patients wanting branded GLP-1s with obesity-medicine oversight and insurance options.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring Knownwell and Amazon One Medical head-to-heads in the same category.
- Knownwell vs CoreAge Rx
- Knownwell vs TrimRx
- Knownwell vs NovoCare Pharmacy
- Amazon One Medical vs Vytora Health
- Amazon One Medical vs Enhance MD
- Amazon One Medical vs Noom Med
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.