HealthRX vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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HealthRX
Best for: flat-price compounded semaglutide or tirzepatide from a LegitScript-certified cash-pay program
Visit HealthRX →
Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →HealthRX and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, HealthRX starts lower at $133/mo versus $149/mo, and HealthRX is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
HealthRX
Flat rate, same price at every dose; 3-month plan from $133/mo, 12-month plan from $99/mo
Flat rate, same price at every dose; 3-month plan from $209/mo, 12-month plan from $179/mo
Amazon One Medical
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What’s included
HealthRX
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
HealthRX
7.3/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | HealthRX | Amazon One Medical |
|---|---|---|
| Starting Price | ✓$133/mo | $149/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | — | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
About HealthRX
HealthRX is a cash-pay telehealth program offering compounded GLP-1 injections — semaglutide and tirzepatide — at flat, dose-independent pricing with free overnight cold shipping and no insurance. A US-licensed clinician reviews a short online assessment within 24 hours and prescribes if appropriate; medication ships from a licensed 503A compounding pharmacy within 24-48 hours. HealthRX is LegitScript-certified (Cert. 50087439) and posts the FDA compounded disclaimer, but it doesn't publicly name its compounding pharmacy, list the states where it prescribes, or name a medical director.
Read our full HealthRX review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
HealthRX
What we like
- LegitScript-certified (Cert. 50087439) and posts the FDA compounded disclaimer — real trust signals for a compounded-GLP-1 program
- Flat, dose-independent pricing — the price doesn't rise as you titrate up; from $99/mo semaglutide and $179/mo tirzepatide on the 12-month plan
- Free overnight cold shipping, no insurance needed, HSA/FSA eligible, and a full refund if a clinician doesn't approve you
- One-click cancellation and a refund on any unshipped dose — no phone-call retention wall
Watch-outs
- Doesn't publicly name its 503A compounding pharmacy — you can't independently verify that part of the supply chain
- Doesn't list the states where it prescribes (only an 'all 50 states' shipping claim); you learn eligibility after the assessment
- No named medical director or clinical leadership; clinicians are independent contractors, not HealthRX staff
- Compounded semaglutide and tirzepatide only — no brand-name (Wegovy/Zepbound) or oral options
- Compounded GLP-1s are not FDA-reviewed or approved — a different evidence and regulatory tier than brand-name
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
HealthRX is our recommended choice here, particularly for flat-price compounded semaglutide or tirzepatide from a LegitScript-certified cash-pay program. Amazon One Medical is a solid alternative, especially if you want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose HealthRX if…
You want flat-price compounded semaglutide or tirzepatide from a LegitScript-certified cash-pay program and a starting price around $133/mo.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
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Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →PeterMD
Men seeking flat-priced compounded GLP-1 access alongside TRT or peptide therapy
From $105/mo
Get started →HealthRX vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.