Fifty 410 vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Fifty 410
Best for Budget-focused buyers wanting transparent no-membership compounded GLP-1 pricingStarting at $99/mo
Amazon One Medical
Best for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savingsStarting at $25/mo
Side-by-Side Comparison
| Feature | Fifty 410 | Amazon One Medical |
|---|---|---|
| Overall Score | 7.0/10 | ✓8.7/10 |
| Starting Price | $99/mo | ✓$25/mo |
| Editorial Rating | 3.5 ★ /5 | ✓4.4 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
Pros & Cons
Fifty 410
Pros
- ✓Transparent public pricing from 99 dollars per month for semaglutide
- ✓No membership or subscription; pay only for what you need
- ✓Compounded by FDA-registered 503A and 503B pharmacies
- ✓Fast 24 to 48 hour provider review
- ✓Free one to two day shipping
- ✓Accepts FSA/HSA plus Afterpay and Affirm
Cons
- ✗Does not bill insurance directly
- ✗Compounded GLP-1 is not an FDA-approved finished drug
- ✗Specific clinician credentials are not publicly disclosed
- ✗Served-states list is not published on the site
- ✗No branded GLP-1 options
Amazon One Medical
Pros
- ✓As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- ✓Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- ✓In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- ✓Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- ✓Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- ✓Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Cons
- ✗Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- ✗Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- ✗Pricing is set by manufacturer savings programs and can change at any time
- ✗No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- ✗Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- ✗Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Fifty 410 with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Fifty 410 remains a solid alternative, especially if you're looking for Budget-focused buyers wanting transparent no-membership compounded GLP-1 pricing.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.