Direct Meds vs ShedRx
In our scoring, ShedRx edges ahead overall (8.0 vs 6.4 out of 10), and ShedRx costs less for compounded semaglutide (about $1,776 a year less).
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Key differences
- Price
- ShedRx $149/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,776 a year less with ShedRx)
- Included
- Direct Meds: medication, clinician visits, shipping; ShedRx: medication, clinician visits, coaching
- Safety
- FDA warning letters on record: Direct Meds 1, ShedRx none
Direct Meds
Affiliate partnerAlso prices oral compounded tirzepatide
semaglutide
$297
Our score 6.4/10
ShedRx
Affiliate partnerBest for compounded GLP-1 as an injection, drops or lozenges, with lower rates on 6- and 12-month plans
semaglutide
$149
Our score 8.0/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
ShedRx
Price
Semaglutide / month
$297/mo
Better on this row: $149/mo
Semaglutide / year (modeled)
$3,564
Better on this row: $1,788
Tirzepatide / month
$399/mo
Better on this row: $199/mo
Tirzepatide / year (modeled)
$4,788
Better on this row: $2,388
Oral semaglutide / month
$249/mo
Better on this row: $199/mo
Oral semaglutide / year (modeled)
$2,988
Better on this row: $2,388
Semaglutide (pill or injection) / month
Not listed
$149/mo
+ separate membership
Oral tirzepatide / month
$299/mo
Not listed
Brand Foundayo / month
Not listed
$149/mo
+ separate membership
Separate membership required
Not stated
Yes — not in the listed price
Coverage
Oral option listed
Yes
Yes
Brand-name access listed
Not listed
Foundayo
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, coaching
Terms & safety
Price shown
Before intake
Plan quoted after intake; a price is published
Video visit
Not disclosed
Not required
Cancel anytime
No
Not disclosed
Minimum commitment
3-month prepay
None
Refunds
Not disclosed
120-day money-back guarantee
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · ShedRx
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- Lists oral compounded tirzepatide, which ShedRx doesn't price
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
What to weigh up
- 1 FDA warning letter on record
- About $1,776 a year more than ShedRx for compounded semaglutide
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
Choose ShedRx if…
- About $1,776 a year less than Direct Meds for compounded semaglutide at standing prices
- Lists compounded semaglutide (pill or injection) and brand-name Foundayo, which Direct Meds doesn't price
- No FDA warning letters on record (Direct Meds has 1)
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
ShedRx
8.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Direct Meds vs ShedRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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