Cost Plus Drugs vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Cost Plus Drugs
Best for the cheapest transparent-pricing brand-name Ozempic channelStarting at $279/mo
Amazon One Medical
Best for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savingsStarting at $25/mo
Side-by-Side Comparison
| Feature | Cost Plus Drugs | Amazon One Medical |
|---|---|---|
| Overall Score | 8.5/10 | ✓8.7/10 |
| Starting Price | $279/mo | ✓$25/mo |
| Editorial Rating | 4.3 ★ /5 | ✓4.4 ★ /5 |
| Features | 5 features | ✓6 features |
| States Available | 50 | 50 |
| Compounded | — | — |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Cost Plus Drugs
Pros
- ✓Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- ✓Around $279/mo for branded Ozempic — well below typical retail list prices
- ✓Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
- ✓Ships to all 50 states; genuine FDA-approved Novo Nordisk Ozempic, not compounded
- ✓Partnered with 9amHealth so you can get prescribed and fill at Cost Plus pricing
Cons
- ✗Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- ✗Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
- ✗Wegovy availability has been spotty — check current stock before assuming it ships
- ✗No compounded semaglutide or tirzepatide — brand only
- ✗No clinical follow-up — side-effect monitoring falls to your prescribing clinician
Amazon One Medical
Pros
- ✓As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- ✓Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- ✓In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- ✓Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- ✓Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- ✓Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Cons
- ✗Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- ✗Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- ✗Pricing is set by manufacturer savings programs and can change at any time
- ✗No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- ✗Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- ✗Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Cost Plus Drugs with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Cost Plus Drugs remains a solid alternative, especially if you're looking for the cheapest transparent-pricing brand-name Ozempic channel.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.