Aspire Health vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Aspire Health
Best for: compounded + brand GLP-1s (Wegovy/Zepbound) with labs included and named PA/NP team in Nebraska telehealth
Visit Aspire Health →
Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →Aspire Health and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $205/mo, and Amazon One Medical edges ahead overall (8.7 vs 6.9 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Aspire Health
Verbatim from weight-loss page: '$149' for 5-week supply of compounded semaglutide/B6 (low dose 0.25–0.5 mg) + $75/month LoseIt program fee = ~$205/month total. 'Medication costs are not included in either program fee.' 15-week supply listed at $399 (~$115/mo for medication alone). program fee enrollment fee $200 ($175 online).
Verbatim from weight-loss page: '$199' for 5-week supply of compounded semaglutide/B6 (high dose 1.7+ mg) + $75/month LoseIt program fee = ~$247/month total. 15-week supply listed at $499 (~$144/mo for medication alone). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$199' for 4-week supply of Wegovy (brand semaglutide, starter doses) + $75/month LoseIt program fee = ~$274/month total. Other Wegovy doses listed at $399/4 weeks (~$474/mo total with program fee). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$249' for 5-week supply of compounded tirzepatide/B6 (2.5 mg) + $75/month LoseIt program fee = ~$289/month total. 15-week supply at $699 (~$202/mo for medication alone). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$349' for 5-week supply of compounded tirzepatide/B6 (5–15 mg) + $75/month LoseIt program fee = ~$375/month total. 15-week supply at $999 (~$289/mo for medication alone). 'Medication costs are not included in either program fee.'
Verbatim from weight-loss page: '$299' for 4-week supply of Zepbound (brand tirzepatide, 2.5 mg) + $75/month LoseIt program fee = ~$374/month total. Higher doses (7.5–15 mg) listed at $449/4wks (~$524/mo total with program fee). 'Medication costs are not included in either program fee.'
Amazon One Medical
What’s included
Aspire Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Included
Coaching
Included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Aspire Health
6.9/10
Amazon One Medical
8.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Aspire Health | Amazon One Medical |
|---|---|---|
| Starting Price | $205/mo | ✓$149/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
About Aspire Health
Aspire Health is a Nebraska-based telehealth practice offering both compounded semaglutide/tirzepatide (formulated with B6) and brand-name Wegovy and Zepbound, prescribed by a named PA/NP clinical team. The LoseIt membership ($200 enrollment + $75/month) includes lab orders with interpretation, provider visits every 2–3 months, Slimpossible app access, and ongoing support — with medication billed separately starting at $149 per 5-week supply for compounded semaglutide.
Read our full Aspire Health review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Aspire Health
What we like
- Both compounded and brand-name options (Wegovy + Zepbound) — rare among GLP-1 telehealth providers
- Lab orders with interpretation included in LoseIt membership — not billed separately
- Named clinical team: founded by Jenni Haan, MPAS, PA-C (18+ years experience) with four additional credentialed providers
- Slimpossible app + secure messaging for ongoing support between provider visits
- HSA/FSA accepted; Cherry third-party financing available for patients needing payment plans
Watch-outs
- Membership fee ($75/month) stacks on top of separately billed medication — total spend $205–$524/month depending on dose
- No LegitScript certification or independent third-party accreditation disclosed
- States served not publicly listed; availability depends on individual provider licensure
- All medication sales are final once shipped; consultation fee non-refundable once completed
- Compounding pharmacy partner not named on any public page
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Aspire Health with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Aspire Health remains a solid alternative, especially if you're looking for compounded + brand GLP-1s (Wegovy/Zepbound) with labs included and named PA/NP team in Nebraska telehealth.
Choose Aspire Health if…
You want compounded + brand GLP-1s (Wegovy/Zepbound) with labs included and named PA/NP team in Nebraska telehealth and a starting price around $205/mo.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
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Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.