Amazon One Medical vs ZYP Medical
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.1 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; ZYP Medical $160/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states; ZYP Medical 7 states (only Amazon One Medical: Alabama, Alaska, Arkansas and 40 more)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); ZYP Medical: medication, clinician visits, shipping
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
ZYP Medical
Best for A free hour-long consult and low-cost compounded GLP-1s in NE, IA, SD, MN, KS, CO or AZ
semaglutide
$160
on a 12-month prepaid plan
Our score 7.1/10
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Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
ZYP Medical
Price
Semaglutide / month
Not listed
$160/mo
on a 12-month prepaid plan
Tirzepatide / month
Not listed
$225/mo
on a 2-month prepaid plan
Oral tirzepatide / month
Not listed
$199/mo
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
7 states
Oral option listed
Yes
Yes
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Cancel anytime
Not disclosed
Yes
Minimum commitment
Not disclosed
None on month-to-month prices
Refunds
Not disclosed
All sales final; prepaid multi-vial plans refund up to $100 if canceled before a later vial ships
Early-cancellation fee
Not disclosed
None
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
October 2026
Show where they differ by stateHide state lists
Only Amazon One Medical (43 states)
- Alabama
- Alaska
- Arkansas
- California
- Connecticut
- Delaware
- Florida
- Georgia
- Hawaii
- Idaho
- Illinois
- Indiana
- Kentucky
- Louisiana
- Maine
- Maryland
- Massachusetts
- Michigan
- Mississippi
- Missouri
- Montana
- Nevada
- New Hampshire
- New Jersey
- New Mexico
- New York
- North Carolina
- North Dakota
- Ohio
- Oklahoma
- Oregon
- Pennsylvania
- Rhode Island
- South Carolina
- Tennessee
- Texas
- Utah
- Vermont
- Virginia
- Washington
- West Virginia
- Wisconsin
- Wyoming
Every dose and plan: Amazon One Medical · ZYP Medical
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which ZYP Medical doesn't price
- Serves 43 states that ZYP Medical doesn't
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Price doesn't include medication
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Choose ZYP Medical if…
- Lists compounded semaglutide, compounded tirzepatide and oral compounded tirzepatide, which Amazon One Medical doesn't price
- Price includes medication; Amazon One Medical's doesn't
- Free one-hour first consult with the provider who manages your care
What to weigh up
- Its $160/mo compounded semaglutide price needs a 12-month prepaid plan
- Not available in 43 states that Amazon One Medical serves
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
ZYP Medical
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Amazon One Medical vs ZYP Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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- ZYP Medical vs Vytora Health
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.