Amazon One Medical vs RxPepsDirect
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.1 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; RxPepsDirect $64/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states; RxPepsDirect 27 states + DC (only Amazon One Medical: Alabama, Arkansas, California and 20 more · only RxPepsDirect: District of Columbia)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); RxPepsDirect: medication, clinician visits, shipping (not included: labs, coaching)
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
RxPepsDirect
Best for Lowest per-vial GLP-1 cost: sema $25, tirz $45, $39 telehealth Rx, 28 states
semaglutide
$64
per vial
Our score 7.1/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
RxPepsDirect
Price
Semaglutide / month
Not listed
$64/mo
per vial
Tirzepatide / month
Not listed
$84/mo
per vial
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
27 states + DC
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication, clinician visits, shipping
Not included: labs, coaching
Terms & safety
Price shown
Before intake
Plan quoted after intake; a price is published
Lab work
Required
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
August 2026
Show where they differ by stateHide state lists
Only RxPepsDirect (DC)
- District of Columbia
Only Amazon One Medical (23 states)
- Alabama
- Arkansas
- California
- Georgia
- Hawaii
- Illinois
- Kentucky
- Maryland
- Massachusetts
- Minnesota
- Mississippi
- Missouri
- Nebraska
- New Mexico
- North Carolina
- Ohio
- Oklahoma
- Oregon
- South Carolina
- South Dakota
- Tennessee
- Virginia
- West Virginia
Every dose and plan: Amazon One Medical · RxPepsDirect
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which RxPepsDirect doesn't price
- Serves 23 states that RxPepsDirect doesn't
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Not available in District of Columbia
- Price doesn't include medication
Choose RxPepsDirect if…
- Lists compounded semaglutide and compounded tirzepatide, which Amazon One Medical doesn't price
- Serves District of Columbia, where Amazon One Medical doesn't
- Price includes medication; Amazon One Medical's doesn't
What to weigh up
- Not available in 23 states that Amazon One Medical serves
- No LegitScript certification; the company was founded in 2026, so there is no public track record or long-term patient-outcomes data
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
RxPepsDirect
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
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From $179/mo
Get started →Found
Medication-included compounded GLP-1 from $169/mo on a 12-month prepaid plan, plus brand insurance help
Read full review →From $169/mo (12-month plan rate)
Get started →GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo (“starting at” price)
Get started →Amazon One Medical vs RxPepsDirect: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking, or alternatives to Amazon One Medical and RxPepsDirect.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.