1st Optimal vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programNewSelf
Best for lowest-cost compounded GLP-1 with pharmacy quality transparencyStarting at $100/mo
Side-by-Side Comparison
| Feature | 1st Optimal | NewSelf |
|---|---|---|
| Overall Score | 6.7/10 | ✓7.8/10 |
| Starting Price | — | $100/mo |
| Editorial Rating | 3.4 ★ /5 | ✓3.9 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓49 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
NewSelf
Pros
- ✓Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- ✓All dosages at the same price — no price escalation as dose increases
- ✓LegitScript certified with 503A licensed pharmacies
- ✓Third-party potency, sterility, and endotoxicity testing
- ✓48 states + Puerto Rico coverage
- ✓B12/B6 + Glycine enhanced formulations
- ✓No membership fees
Cons
- ✗Not available in Mississippi and Louisiana
- ✗Compounded only — no brand-name options
- ✗Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out 1st Optimal with a higher overall score of 7.8/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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