1st Optimal vs MyFastRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
MyFastRx
Best for: 12-month upfront billing for the lowest compounded-GLP-1 monthly rate.
Visit MyFastRx →1st Optimal and MyFastRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both start around $99/mo, and MyFastRx edges ahead overall (7.0 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
MyFastRx
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
MyFastRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
MyFastRx
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | MyFastRx |
|---|---|---|
| Starting Price | $99/mo | $99/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About MyFastRx
MyFastRx is a cash-pay compounded-GLP-1 platform built around fast approval and discounted multi-month bundles. Compounded semaglutide runs $169/mo standard, dropping to $99/mo on a 12-month prepay; tirzepatide is $249/mo standard, down to $149/mo on 12 months — all doses priced the same with a SAVE70 first-month promo. It accepts no insurance and ships nationwide; LegitScript-listed and HIPAA-compliant.
Read our full MyFastRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
MyFastRx
What we like
- Aggressive 12-month bundle pricing — $99/mo semaglutide, $149/mo tirzepatide
- LegitScript certified
- All doses priced the same — no cost escalation as you titrate up
- First-month promo discount lowers the trial barrier
Watch-outs
- States served not disclosed — only 'multiple states' / 'licensed U.S. providers'
- Corporate address and medical director not published
- Pharmacy partner not named — only 'state-licensed pharmacies'
- Cash-pay only — no insurance billing
- Bundle savings require a large upfront commitment (12 months billed at once)
Our Verdict
MyFastRx edges out 1st Optimal with a higher overall score of 7.0/10 and is particularly strong for 12-month upfront billing for the lowest compounded-GLP-1 monthly rate.. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose MyFastRx if…
You want 12-month upfront billing for the lowest compounded-GLP-1 monthly rate. and a starting price around $99/mo.
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Brightmeds
Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →Direct Meds
Listed for disclosure only — see its FDA warning and BBB complaints first
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →1st Optimal vs MyFastRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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