1st Optimal vs Joi + Blokes
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programJoi + Blokes
Best for GLP-1 alongside men's and women's hormone-health programsStarting at $99/mo
Side-by-Side Comparison
| Feature | 1st Optimal | Joi + Blokes |
|---|---|---|
| Overall Score | 6.7/10 | ✓8.0/10 |
| Starting Price | — | $99/mo |
| Editorial Rating | 3.4 ★ /5 | ✓4 ★ /5 |
| Features | ✓8 features | 7 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
Joi + Blokes
Pros
- ✓Separate programs for women (Joi) and men (Blokes) — most GLP-1 telehealth is gender-agnostic
- ✓Trustpilot 4.6/5 from 1,254+ reviews — among the strongest review signals in the category
- ✓Monthly price includes medication, dosing support, clinician consults, and health coaching
- ✓Integrated hormone + GLP-1 programs help patients on testosterone or perimenopausal protocols
- ✓First-month discount ($99 sema / $149 tirz) lowers the barrier to trying GLP-1s
Cons
- ✗Billed quarterly — a 3-month commitment up front, not month-to-month
- ✗Different pricing in NY and NJ — verify your state's cost before committing
- ✗Per-state availability isn't listed; it's zip-code gated behind signup
- ✗Months 2+ cost more ($199 sema / $299 tirz) than the headline intro price
- ✗No FDA-approved Wegovy — compounded only on the GLP-1 side; Zepbound carries a separate visit fee
- ✗No LegitScript or PCAB accreditation badge visible
Our Verdict
Joi + Blokes edges out 1st Optimal with a higher overall score of 8.0/10 and is particularly strong for GLP-1 alongside men's and women's hormone-health programs. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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