1st Optimal vs Human+
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →Human+
Best for: pharmacy-wholesale pricing via a flat membership, in any state
Visit Human+ →1st Optimal and Human+ are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Human+ edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Human+
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Billed separately
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Human+
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Human+ |
|---|---|---|
| Starting Price | — | — |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Human+
Human+ (HUMAN+, INC.) is an 'at-cost' telehealth membership in all 50 states: you pay a flat monthly fee and prescriptions are billed at pharmacy-wholesale cost rather than marked up. Weight loss is one of its treatment categories (with hair, sexual wellness, mental health, and labs), filled through US 503A compounding pharmacies and reviewed by board-certified clinicians after a 5-minute intake. Medicine ships in plain packaging. Specific GLP-1 medications and pricing are shown during intake, not published publicly; compounded medications are not FDA-approved.
Read our full Human+ review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Human+
What we like
- Cost-transparent model: a flat monthly membership with prescriptions billed at pharmacy-wholesale cost instead of marked up
- Available via telehealth in all 50 states
- Filled by US 503A compounding pharmacies and reviewed by board-certified US-licensed clinicians
- Fast, fully online 5-minute intake with provider review often within hours; discreet plain packaging
- Covers weight loss plus hair, sexual wellness, mental health, and labs under one membership
Watch-outs
- Specific GLP-1 medications and pricing are not published — you only see them after starting the intake
- Compounded medications are not FDA-approved — not brand Wegovy, Ozempic, Zepbound, or Mounjaro
- LegitScript certification is shown only as a self-hosted badge; no verifiable LegitScript seal was found
- Minimal public-facing site and a flat membership fee on top of the medication cost
Our Verdict
Human+ edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for pharmacy-wholesale pricing via a flat membership, in any state. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Human+ if…
You want pharmacy-wholesale pricing via a flat membership, in any state.
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SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →YourEra
$99 first-month entry pricing on compounded GLP-1s
From $99/mo
Get started →Gala
Compounded GLP-1/GIP combo on a yearly plan with free shipping
From $129/mo
Get started →1st Optimal vs Human+: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.