1st Optimal vs HealthRX
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →HealthRX
Best for: flat-price compounded GLP-1, LegitScript-certified cash-pay program
Visit HealthRX →1st Optimal and HealthRX are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $133/mo, and HealthRX edges ahead overall (7.3 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
HealthRX
Flat rate, same price at every dose; 3-month plan from $133/mo, 12-month plan from $99/mo
Flat rate, same price at every dose; 3-month plan from $209/mo, 12-month plan from $179/mo
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
HealthRX
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
HealthRX
7.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | HealthRX |
|---|---|---|
| Starting Price | ✓$99/mo | $133/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About HealthRX
HealthRX is a cash-pay telehealth program offering compounded GLP-1 injections — semaglutide and tirzepatide — at flat, dose-independent pricing with free overnight cold shipping and no insurance. A US-licensed clinician reviews a short online assessment within 24 hours and prescribes if appropriate; medication ships from a licensed 503A compounding pharmacy within 24-48 hours. HealthRX is LegitScript-certified (Cert. 50087439) and posts the FDA compounded disclaimer, but it doesn't publicly name its compounding pharmacy, list the states where it prescribes, or name a medical director.
Read our full HealthRX review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
HealthRX
What we like
- LegitScript-certified (Cert. 50087439) and posts the FDA compounded disclaimer — real trust signals for a compounded-GLP-1 program
- Flat, dose-independent pricing — the price doesn't rise as you titrate up; from $99/mo semaglutide and $179/mo tirzepatide on the 12-month plan
- Free overnight cold shipping, no insurance needed, HSA/FSA eligible, and a full refund if a clinician doesn't approve you
- One-click cancellation and a refund on any unshipped dose — no phone-call retention wall
Watch-outs
- Doesn't publicly name its 503A compounding pharmacy — you can't independently verify that part of the supply chain
- Doesn't list the states where it prescribes (only an 'all 50 states' shipping claim); you learn eligibility after the assessment
- No named medical director or clinical leadership; clinicians are independent contractors, not HealthRX staff
- Compounded semaglutide and tirzepatide only — no brand-name (Wegovy/Zepbound) or oral options
- Compounded GLP-1s are not FDA-reviewed or approved — a different evidence and regulatory tier than brand-name
Our Verdict
HealthRX edges out 1st Optimal with a higher overall score of 7.3/10 and is particularly strong for flat-price compounded GLP-1, LegitScript-certified cash-pay program. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose HealthRX if…
You want flat-price compounded GLP-1, LegitScript-certified cash-pay program and a starting price around $133/mo.
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Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →TrimRx
Best overall value
From $149/mo
Get started →Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →1st Optimal vs HealthRX: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.