1st Optimal vs Eviora MD
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Eviora MD
Best for: a supervised microdose GLP-1 protocol, if you can absorb the price
Visit Eviora MD →1st Optimal and Eviora MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $299/mo, and 1st Optimal edges ahead overall (6.7 vs 6.5 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Eviora MD
'GLP-1 Microdose', priceNote 'Available by consultation'. Read from the site's own treatment catalog; no price is printed on the page.
priceNote 'Available by consultation'. Read from the site's own treatment catalog; no price is printed on the page.
priceNote 'Available by consultation'. Read from the site's own treatment catalog; no price is printed on the page.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Eviora MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Eviora MD
6.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Eviora MD |
|---|---|---|
| Starting Price | ✓$99/mo | $299/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Eviora MD
Eviora MD is a cash-pay telehealth platform selling three compounded GLP-1 programs: a microdose at $249/mo, semaglutide at $299/mo and tirzepatide at $399/mo, each all-in with provider oversight, titration, secure messaging and unmarked home delivery. Those figures come from the site's own commerce data — the 'from $149/mo' its pages advertise is not the price of any program it sells.
Read our full Eviora MD review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Eviora MD
What we like
- Three distinct programs including a lower-dose microdose protocol at $249/mo, an option many sellers do not offer
- Flat-rate programs with no separate consult or membership fee
- Free 2-3 day shipping in unmarked, temperature-controlled packaging
- You are not charged if a provider does not approve you — '$0 if you're not approved'
- Provider-directed titration, structured check-ins and secure direct messaging are named as part of the price
- Eligibility criteria are published up front: adults 18+ with BMI 27+, or 25+ with a weight-related condition
Watch-outs
- The advertised 'from $149/mo' matches no program Eviora sells — its own catalog prices them at $249, $299 and $399
- $299 for compounded semaglutide and $399 for tirzepatide are near the top of the range we track
- No price is printed anywhere on the site; every program reads 'Available by consultation'
- A 'Trustpilot · Excellent · 4.8 / 5' badge runs on the homepage, but no Trustpilot profile exists for evioramd.com or the Eviora brand
- Billing recurs 'every 30 days', which is 13 charges in a year rather than 12
- Canceling a membership requires 30 days' notice, and orders can only be canceled within 24 hours if unshipped
- The compounding pharmacy is never named — only 'partner compounding pharmacies'
- No state list is published, and no phone number appears anywhere on the site
Our Verdict
1st Optimal edges out Eviora MD with a higher overall score of 6.7/10 and is particularly strong for GLP-1 therapy within a lab-driven functional-medicine program. Eviora MD remains a solid alternative, especially if you're looking for a supervised microdose GLP-1 protocol, if you can absorb the price.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Eviora MD if…
You want a supervised microdose GLP-1 protocol, if you can absorb the price and a starting price around $299/mo.
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Get started →1st Optimal vs Eviora MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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