1st Optimal vs EOS Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
EOS Health
Best for: compounded GLP-1 with openly named clinical and pharmacy partners
Visit EOS Health →1st Optimal and EOS Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $279.99/mo, and EOS Health edges ahead overall (7.8 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
EOS Health
$179.99 for a first month, then $279.99 recurring. Each price is all-in: consultation, medication, shipping and injection supplies, and it does not change with your dose.
'Advanced GLP-1 + GIP': $279.99 for a first month, then $379.99 recurring, on the same all-in, dose-flat terms.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
EOS Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
EOS Health
7.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | EOS Health |
|---|---|---|
| Starting Price | ✓$99/mo | $279.99/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 40 |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About EOS Health
EOS Health is an online telehealth service offering compounded GLP-1 programs. After a short questionnaire and clinician review it prescribes two products — 'Compounded GLP-1' at $179.99 first month then $279.99/month, and 'Advanced GLP-1 + GIP' at $279.99 then $379.99/month. Each price is all-in: consultation, medication, shipping and injection supplies, and the rate is flat regardless of dose. The site no longer names semaglutide or tirzepatide, no longer publishes the WELCOME100 code or the $229 glycine/B12 formulas, and describes its coverage only as 'multiple states'.
Read our full EOS Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
EOS Health
What we like
- Unusually transparent: publicly names its clinical partner (Arora Health & Aesthetics, LLC) and pharmacy partner (F&F Pharmacies dba Jungle Jim's)
- Competitive compounded pricing from $199/mo semaglutide and $289/mo tirzepatide, plus $100 off the first prescription with code WELCOME100
- Multiple compounded formulas (semaglutide, semaglutide+glycine, semaglutide+B12, tirzepatide) and optional 130+ biomarker lab add-ons
- Free expedited shipping, no insurance required, 10-minute intake, and an ongoing care team via patient portal
Watch-outs
- Available in only 40 states — not offered in CA, NV, NJ, SC, TX, MA, MS, NH, WV, or DE (pharmacy partner is unlicensed there)
- Headline prices are 'best rate' figures; standard monthly plans may cost more than the quarterly-plan rate shown
- Compounded medication only — no brand-name or insurance-covered GLP-1 path
- Pharmacy partner's page notes it 'cannot dispense sterile compounds,' which is worth confirming for injectable GLP-1 fulfillment
Our Verdict
EOS Health edges out 1st Optimal with a higher overall score of 7.8/10 and is particularly strong for compounded GLP-1 with openly named clinical and pharmacy partners. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose EOS Health if…
You want compounded GLP-1 with openly named clinical and pharmacy partners and a starting price around $279.99/mo.
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SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →Embody
Low flat-rate compounded GLP-1 pricing at every dose
From $79/mo
Get started →YourEra
$99 first-month entry pricing on compounded GLP-1s
From $149/mo
Get started →1st Optimal vs EOS Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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