1st Optimal vs EOS Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
EOS Health
Best for: people who want compounded GLP-1 from a provider that openly names its clinical and pharmacy partners
Visit EOS Health →1st Optimal and EOS Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, EOS Health starts at $199/mo, and EOS Health edges ahead overall (7.8 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
EOS Health
Compounded semaglutide once-weekly injection from $199/mo (best rate; monthly and quarterly plans available). Sema+glycine and sema+B12 formulas from $229/mo. New patients save $100 with code WELCOME100.
Compounded tirzepatide (dual GLP-1/GIP) once-weekly injection from $289/mo (best rate; monthly and quarterly plans available). New patients save $100 with code WELCOME100.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
EOS Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
EOS Health
7.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | EOS Health |
|---|---|---|
| Starting Price | — | $199/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 40 |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About EOS Health
EOS Health is a multi-vertical online telehealth service (weight loss, longevity, men's/women's health, skincare) offering compounded GLP-1 programs. After a short questionnaire and clinician review, it prescribes compounded semaglutide from $199/month (glycine or B12 formulas $229) and tirzepatide from $289/month, with free shipping and no insurance required. It is unusually transparent, naming its clinical partner (Arora Health & Aesthetics) and pharmacy partner (Jungle Jim's), and new patients save $100 with code WELCOME100. Service covers the 40 states its pharmacy partner is licensed in.
Read our full EOS Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
EOS Health
What we like
- Unusually transparent: publicly names its clinical partner (Arora Health & Aesthetics, LLC) and pharmacy partner (F&F Pharmacies dba Jungle Jim's)
- Competitive compounded pricing from $199/mo semaglutide and $289/mo tirzepatide, plus $100 off the first prescription with code WELCOME100
- Multiple compounded formulas (semaglutide, semaglutide+glycine, semaglutide+B12, tirzepatide) and optional 130+ biomarker lab add-ons
- Free expedited shipping, no insurance required, 10-minute intake, and an ongoing care team via patient portal
Watch-outs
- Available in only 40 states — not offered in CA, NV, NJ, SC, TX, MA, MS, NH, WV, or DE (pharmacy partner is unlicensed there)
- Headline prices are 'best rate' figures; standard monthly plans may cost more than the quarterly-plan rate shown
- Compounded medication only — no brand-name or insurance-covered GLP-1 path
- Pharmacy partner's page notes it 'cannot dispense sterile compounds,' which is worth confirming for injectable GLP-1 fulfillment
Our Verdict
EOS Health edges out 1st Optimal with a higher overall score of 7.8/10 and is particularly strong for people who want compounded GLP-1 from a provider that openly names its clinical and pharmacy partners. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose EOS Health if…
You want people who want compounded GLP-1 from a provider that openly names its clinical and pharmacy partners and a starting price around $199/mo.
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RxSpan MD
Shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →1st Optimal vs EOS Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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