1st Optimal vs Clume Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Clume Health
Best for: readers who want a separately priced microdose track and named dispensing pharmacies
Visit Clume Health →1st Optimal and Clume Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $219/mo, and Clume Health edges ahead overall (7.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Clume Health
The $186/mo figure is a 52-week prepaid term, not an ongoing monthly rate.
The $186/mo figure is a 52-week prepaid term, not an ongoing monthly rate.
The $200/mo figure requires a 12-week prepaid term.
The $200/mo figure requires a 12-week prepaid term.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Clume Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Clume Health
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Clume Health |
|---|---|---|
| Starting Price | ✓$99/mo | $219/mo |
| Features | ✓8 features | 5 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Clume Health
Clume Health sells compounded semaglutide and tirzepatide in oral and injectable form across three tiers: a full-dose Signature program from $259/mo, a Microdose/Maintain program from $219/mo, and an NAD+ and sermorelin longevity track. Its terms name four dispensing pharmacies outright, which most compounded sellers will not do. Clinical care runs through OpenLoop, and cheaper per-month rates are available only by prepaying a 12- or 52-week term.
Read our full Clume Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Clume Health
What we like
- Names four dispensing pharmacies in its terms, a level of disclosure most compounded sellers avoid.
- Offers both full-dose and microdose tracks, so maintenance has its own priced program.
- Sells semaglutide and tirzepatide in oral as well as injectable form.
- Lists what the monthly price covers, including consultation, medication and at-home delivery.
- Cancellation is allowed at any time by email or through the patient portal.
Watch-outs
- The homepage advertises "starting at *$199/month" and "*$159/month", but no program is priced at either figure.
- Those asterisks lead to no footnote anywhere on the page.
- The cheapest advertised rates require prepaying a full term — $186/mo means a 52-week commitment.
- Canceling needs 72 hours' notice before the next billing date or you are charged for that cycle.
- No refund is issued for the month in which you cancel, or for any prior month.
- Personalized options appear only after you accept OpenLoop's telehealth consent.
- No LegitScript seal or other verified trust badge appears anywhere on the site.
- Support is email only; no phone number or published hours.
Our Verdict
Clume Health edges out 1st Optimal with a higher overall score of 7.1/10 and is particularly strong for readers who want a separately priced microdose track and named dispensing pharmacies. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Clume Health if…
You want readers who want a separately priced microdose track and named dispensing pharmacies and a starting price around $219/mo.
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Compounded GLP-1 access with oral tablet options across 49 states
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Get started →1st Optimal vs Clume Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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