10rx vs Sipra
An in-depth comparison of two leading GLP-1 Providers
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Sipra
Best for: compounded GLP-1 shoppers willing to prepay three months or more for one price at every dose
Visit Sipra →10rx and Sipra are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $96.67/mo versus $149/mo, and both land at 7.1/10 overall. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
Sipra
Shortest plan offered. 6-month plan $169/mo ($1,014 up front); 12-month plan $149/mo ($1,788 up front).
Shortest plan offered. 6-month plan $219/mo ($1,314 up front); 12-month plan $199/mo ($2,388 up front).
Low-dose program. 6-month plan $129/mo ($774 up front); 12-month plan $119/mo ($1,428 up front).
Low-dose program. 6-month plan $179/mo ($1,074 up front); 12-month plan $159/mo ($1,908 up front).
Daily tablet with B6. 6-month plan $219/mo ($1,314 up front); 12-month plan $199/mo ($2,388 up front).
Daily tablet. 6-month plan $249/mo ($1,494 up front); 12-month plan $239/mo ($2,868 up front).
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Sipra
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
Sipra
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | Sipra |
|---|---|---|
| Starting Price | ✓$96.67/mo | $149/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About Sipra
Sipra is a telehealth platform that prescribes compounded semaglutide and tirzepatide as weekly injections, lower-dose microdose injections or dissolving tablets, with physicians from MDI Medical Group. There is no month-to-month option: the shortest plan is three months, paid up front once a physician approves, at $189/mo for semaglutide and $249/mo for tirzepatide. Longer plans cost less per month, the price does not rise with your dose, and shipping is free.
Read our full Sipra review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to pin down
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
Sipra
What we like
- Every plan length, monthly rate and plan total is published on the pricing page before you answer a single question
- One price at every dose: the rate is set by plan length and does not rise as your physician steps the dose up
- Medication, physician review, dose changes, messaging and expedited shipping are in the plan price, with no membership fee
- Your card is charged only after a physician approves treatment; if treatment is declined, you owe nothing
- Six GLP-1 formats: semaglutide or tirzepatide as weekly injections, lower-dose microdose injections or dissolving tablets
- Names its prescribing group (MDI Medical Group) and its pharmacy partners in its terms
- Cancel online in your account, with no phone call or retention script
- HSA and FSA eligible; metformin, low-dose naltrexone, menopause hormone therapy and a lab panel are on the same account
Watch-outs
- No month-to-month option: the shortest plan is three months, charged as one up-front payment (for example, $567 for semaglutide)
- The headline "from $149/mo" is the 12-month rate; standard semaglutide costs $189/mo on the shortest plan
- Three-month plans are not refundable once a physician approves, even if nothing has shipped yet
- Leaving a 6- or 12-month plan early re-prices the months you keep at the higher shorter-plan rate before the rest is refunded
- Plans renew automatically at the rate posted at renewal; cancel at least 13 days before the period ends to stop the next order
- No phone support is published; help is by email, on-site chat and portal messaging
- A new brand: its current terms and refund policy took effect in October 2026, so there is little track record to judge
- Compounded semaglutide and tirzepatide are not FDA-approved
Our Verdict
Both 10rx and Sipra score equally well overall — the right choice depends on your priorities.
Choose 10rx if…
You want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $96.67/mo.
Choose Sipra if…
You want compounded GLP-1 shoppers willing to prepay three months or more for one price at every dose and a starting price around $149/mo.
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Ivim Health
Budget-conscious shoppers
From $75/mo
Get started →Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →AgelessRx
Longevity-focused GLP-1 care
From $139/mo
Get started →10rx vs Sipra: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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