Major trials

SELECT

The pivotal Phase 3 trials and post-approval cardiovascular, kidney, and sleep-apnea outcome studies.

Definition

Cardiovascular outcomes trial of semaglutide 2.4 mg in 17,604 non-diabetic adults with overweight/obesity and established CV disease (Lincoff et al, NEJM 2023). Major adverse cardiovascular events reduced 20% (HR 0.80, 95% CI 0.72-0.90).

SELECT trial cardiovascular benefits

Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in Major trials

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