NewSelf vs Trillium Meds
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Trillium Meds
Best for: LegitScript-certified compounded GLP-1, all 50 states + PR; sema $119/mo
Visit Trillium Meds →NewSelf and Trillium Meds are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $119/mo, and NewSelf edges ahead overall (8.3 vs 7.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Trillium Meds
Verbatim site meta: 'pricing from $109.' 3-month plan at $119/mo ($357 total); 1-month plan at $159/mo. All-inclusive price covers compounded semaglutide (with B6, dispensed by BPI Labs or ProRx pharmacy), provider consultation, and shipping. No additional fees.
3-month plan at $199/mo ($599 total); 1-month plan at $249/mo. All-inclusive price covers compounded tirzepatide (with B6, dispensed by BPI Labs or ProRx pharmacy), provider consultation, and shipping. No additional fees.
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Trillium Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Billed separately
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Trillium Meds
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Trillium Meds |
|---|---|---|
| Starting Price | ✓$100/mo | $119/mo |
| Features | 6 features | ✓8 features |
| States Available | 49 | ✓52 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | 1 warning | ✓None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Trillium Meds
Trillium Meds is a small, owner-operated telehealth platform based in Portland, OR that connects patients with independent licensed providers and FDA-registered compounding pharmacies for compounded semaglutide and tirzepatide. Pricing is all-inclusive—covering medication, provider consultation, and shipping—with no membership fees and flexible 1-month, 3-month fixed-dose, or 3-month titrated programs. LegitScript certified and available in all 50 states plus Puerto Rico.
Read our full Trillium Meds review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Trillium Meds
What we like
- LegitScript certified with an active seal; serves all 50 states plus Puerto Rico with no geographic restrictions
- All-inclusive pricing covers medication, provider consultation, and shipping with no hidden fees or add-ons
- Two pharmacy options (BPI Labs with B6, ProRx) and three plan structures: 1-month, 3-month fixed, or 3-month titrated
- Small owner-operated; founder personally handles customer support outside business hours for direct, responsive service
- Klarna and Affirm financing available; pause anytime with no long-term commitment required
Watch-outs
- No labs, coaching, or clinical monitoring included — telehealth Rx and pharmacy fulfillment only
- Small single-operator platform may limit capacity and support consistency as patient volume grows
- Compounded medications are not FDA-approved; newer platform with limited long-term public track record
- Tirzepatide from $199/mo (3-mo plan) is mid-market; sema from $119/mo competitive but not lowest available
- No live video consult disclosed; async intake-form-based provider review by external licensed provider network
Our Verdict
NewSelf edges out Trillium Meds with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Trillium Meds remains a solid alternative, especially if you're looking for LegitScript-certified compounded GLP-1, all 50 states + PR; sema $119/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Trillium Meds if…
You want LegitScript-certified compounded GLP-1, all 50 states + PR; sema $119/mo and a starting price around $119/mo.
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Get started →NewSelf vs Trillium Meds: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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