NewSelf vs Enhance MD
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for lowest-cost compounded GLP-1 with pharmacy quality transparencyStarting at $100/mo
Enhance MD
Best for lab-monitored compounded GLP-1 with mandatory video visitStarting at $49/mo
Side-by-Side Comparison
| Feature | NewSelf | Enhance MD |
|---|---|---|
| Overall Score | 7.8/10 | ✓8.6/10 |
| Starting Price | $100/mo | ✓$49/mo |
| Editorial Rating | 3.9 ★ /5 | ✓4.3 ★ /5 |
| Features | 5 features | ✓6 features |
| States Available | ✓49 | 39 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
NewSelf
Pros
- ✓Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- ✓All dosages at the same price — no price escalation as dose increases
- ✓LegitScript certified with 503A licensed pharmacies
- ✓Third-party potency, sterility, and endotoxicity testing
- ✓48 states + Puerto Rico coverage
- ✓B12/B6 + Glycine enhanced formulations
- ✓No membership fees
Cons
- ✗Not available in Mississippi and Louisiana
- ✗Compounded only — no brand-name options
- ✗Site also promotes AI health optimization and longevity (broader platform)
Enhance MD
Pros
- ✓Baseline and ongoing metabolic lab panels (CMP, lipids, TSH, HbA1c) at Quest Diagnostics every 6 months — a rigor most compounded GLP-1 providers skip entirely
- ✓Mandatory one-on-one video visit with a US-licensed MD or NP before the first prescription — not a pure-async questionnaire model
- ✓Three pricing tiers including a combined semaglutide + tirzepatide Elite plan ($322/mo ongoing) — useful for patients plateaued on a single GLP-1
- ✓LegitScript-certified 503A pharmacy network: Tru Meds Rx, Strive Pharmacy, Pharmacy Hub
- ✓Aggressive first-month intro pricing: $49 on Core, $99 on Advanced, $189 on Elite
- ✓Unlimited clinician messaging and dose-adjustment support included
Cons
- ✗Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro option
- ✗Not available in 10 states: Alabama, Arkansas, Georgia, Hawaii, Louisiana, Mississippi, Missouri, South Carolina, Tennessee, West Virginia
- ✗Mandatory lab work adds 5–10 days to onboarding vs. async-only competitors
- ✗No insurance accepted — cash pay, HSA/FSA eligible
- ✗First-month intro pricing resets to full tier rate after 30 days — the $49/$99/$189 numbers are not the ongoing cost
Our Verdict
Enhance MD edges out NewSelf with a higher overall score of 8.6/10 and is particularly strong for lab-monitored compounded GLP-1 with mandatory video visit. NewSelf remains a solid alternative, especially if you're looking for lowest-cost compounded GLP-1 with pharmacy quality transparency.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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- NewSelf vs Amazon One Medical
- Enhance MD vs NovoCare Pharmacy
- Enhance MD vs Vytora Health
- Enhance MD vs Noom Med
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.