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LifespanningRx vs NewSelf

An in-depth comparison of two leading GLP-1 Providers

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By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed
LifespanningRx logo

LifespanningRx

6.9
★★★3.5/5

Best for: Compounded GLP-1 weight loss inside a longevity and peptide telehealth brand

Visit LifespanningRx
VS
NewSelf logo

NewSelf

8.3
★★★★4.2/5

Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency

Visit NewSelf

LifespanningRx and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts at $100/mo, and NewSelf edges ahead overall (8.3 vs 6.9 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.

Pricing

LifespanningRx

Pricing not publicly listed.

NewSelf

Semaglutide+ (best price)Compounded
$100/mo
semaglutide

All dosages same price

Semaglutide+ (regular)Compounded
$135/mo
semaglutide
Tirzepatide+ (best price)Compounded
$144/mo
tirzepatide

All dosages same price

Tirzepatide+ (regular)Compounded
$225/mo
tirzepatide

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What’s included

LifespanningRx

What the monthly price covers

Medication

Included

Provider visits

Included

Shipping

Included

Lab work

Not disclosed

Coaching

Not disclosed

NewSelf

What the monthly price covers

Medication

Included

Provider visits

Included

Shipping

Included

Lab work

Not disclosed

Coaching

Not disclosed

Score breakdown

Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.

LifespanningRx

6.9/10

Overall

NewSelf

8.3/10

Value25%

6.5A
vs
B
9.0

Effectiveness25%

7.0A
vs
B
8.0

User Experience15%

7.0A
vs
B
8.0

Trust & Safety15%

7.0A
vs
B
8.3

Accessibility10%

6.5A
vs
B
8.5

Support10%

7.5A
vs
B
7.9

Features & Coverage

FeatureLifespanningRxNewSelf
Starting Price$100/mo
Features8 features6 features
States Available5049
Compounded✓ Yes
Brand Name
FSA/HSA Accepted
FDA WarningsNoneNone

About LifespanningRx

LifespanningRx is a clinician-guided longevity and peptide telehealth brand whose Weight Loss Program prescribes compounded GLP-1 (semaglutide/tirzepatide) injectables alongside peptide and healthy-aging protocols. Medications are compounded through 503A/503B licensed US pharmacies after a provider review and good-faith exam, with discreet nationwide shipping and licensed clinicians included. It also runs a turnkey white-label platform that lets clinics and wellness brands launch these programs. LegitScript-certified and HIPAA-compliant.

Read our full LifespanningRx review →

About NewSelf

NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.

Read our full NewSelf review →

Pros & Cons

LifespanningRx

What we like

  • Compounded GLP-1 (semaglutide/tirzepatide) weight-loss program with licensed clinicians included
  • LegitScript-certified and HIPAA-compliant; works with 503A/503B licensed US pharmacies
  • Longevity and peptide protocols alongside weight loss; free membership, no monthly fee
  • Discreet nationwide shipping with 24/365 support
  • Also a turnkey white-label platform for clinics and wellness brands to launch programs

Watch-outs

  • Exact dosing and pricing are shown only after completing the patient assessment
  • Compounded GLP-1s are not FDA-approved finished products
  • States served are not publicly listed
  • Part B2B/white-label, so the consumer experience can vary by partnered clinic

NewSelf

What we like

  • Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
  • All dosages at the same price — no price escalation as dose increases
  • LegitScript certified with 503A licensed pharmacies
  • Third-party potency, sterility, and endotoxicity testing
  • 48 states + Puerto Rico coverage
  • B12/B6 + Glycine enhanced formulations
  • No membership fees

Watch-outs

  • Not available in Mississippi and Louisiana
  • Compounded only — no brand-name options
  • Site also promotes AI health optimization and longevity (broader platform)

Our Verdict

Winner: NewSelf

NewSelf edges out LifespanningRx with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. LifespanningRx remains a solid alternative, especially if you're looking for Compounded GLP-1 weight loss inside a longevity and peptide telehealth brand.

Choose LifespanningRx if…

You want Compounded GLP-1 weight loss inside a longevity and peptide telehealth brand.

Choose NewSelf if…

You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.

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8.1

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8.0

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LifespanningRx vs NewSelf: FAQ

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