Helix Wellness Rx vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Helix Wellness Rx
Best for: self-serve cancellation and a low-dose GLP-1 entry point
Visit Helix Wellness Rx →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Helix Wellness Rx and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $149/mo, and NewSelf edges ahead overall (8.3 vs 6.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Helix Wellness Rx
$149/mo is the advertised floor across all GLP-1 and peptide programs, not a semaglutide price. The site states "Plans from $149/mo · confirmed after provider review" and the semaglutide, tirzepatide and microdose pages publish no price at all.
NewSelf
All dosages same price
All dosages same price
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What’s included
Helix Wellness Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Helix Wellness Rx
6.3/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Helix Wellness Rx | NewSelf |
|---|---|---|
| Starting Price | $149/mo | ✓$100/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About Helix Wellness Rx
Helix Wellness Rx offers physician-guided semaglutide, tirzepatide and a low-dose GLP-1 microdose alongside a long list of peptide and hormone programs. Programs are advertised from $149/mo, but no per-drug price is published anywhere — the site states cost is "confirmed after provider review". Cancellation is self-serve from the user portal up to 48 hours before the billing date.
Read our full Helix Wellness Rx review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Helix Wellness Rx
What we like
- Self-serve cancellation from the user portal, up to 48 hours before the billing date
- Three GLP-1 routes including a low-dose microdose entry point
- Free 2-3 day shipping and no insurance required
- Pre-screening opens with a goals question rather than a request for contact details
- Publishes a toll-free support line
Watch-outs
- No per-drug price is published — semaglutide, tirzepatide and microdose pages all show no cost at all
- The only figure given is a $149/mo floor spanning GLP-1s and peptides, "confirmed after provider review"
- The privacy page publishes a placeholder phone number, (555) 000-0000
- Pharmacy and medical groups are named as third-party beneficiaries in the terms but never identified
- No state list is published
- Advertises peptides whose regulatory status shifted in 2026 — check what is actually available before ordering one
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Helix Wellness Rx with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Helix Wellness Rx remains a solid alternative, especially if you're looking for self-serve cancellation and a low-dose GLP-1 entry point.
Choose Helix Wellness Rx if…
You want self-serve cancellation and a low-dose GLP-1 entry point and a starting price around $149/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →TrimRx
Best overall value
From $149/mo
Get started →Helix Wellness Rx vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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