FlyteHealth vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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FlyteHealth
Best for: Members of employers or health plans wanting physician-led obesity care
Visit FlyteHealth →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →FlyteHealth and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts at $100/mo, and NewSelf edges ahead overall (8.3 vs 6.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
FlyteHealth
Pricing not publicly listed.
NewSelf
All dosages same price
All dosages same price
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What’s included
FlyteHealth
Inclusions not disclosed.
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
FlyteHealth
6.8/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | FlyteHealth | NewSelf |
|---|---|---|
| Starting Price | — | $100/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About FlyteHealth
FlyteHealth is an obesity-medicine telehealth platform distributed mainly through employers, payers, and health plans, with care led by board-certified obesity-medicine physicians plus nurse practitioners, dietitians, and care coordinators. GLP-1s may be prescribed when appropriate, alongside non-GLP-1 anti-obesity drugs, labs, nutrition, and lifestyle support. It is not a direct cash-pay GLP-1 vendor, though individuals can access it via the MDsave/Tendo marketplace and a FlyteHealth Direct self-pay option. Reported outcomes include roughly 13 to 16 percent weight loss over twelve months.
Read our full FlyteHealth review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
FlyteHealth
What we like
- Care led by board-certified obesity-medicine physicians
- Multidisciplinary team with NPs, dietitians, and care coordinators
- Published outcomes of about 13 to 16 percent weight loss over 12 months
- High GLP-1 medication adherence (around 86 percent in reported data)
- Comprehensive cardiometabolic care beyond GLP-1 alone
- MDsave and FlyteHealth Direct give some self-pay access
Watch-outs
- Distributed primarily via employers, payers, and health plans, not direct cash-pay
- Access is largely gated behind employer or plan sponsorship
- GLP-1 is prescribed only when appropriate, not guaranteed
- Self-pay pricing is not publicly listed (contact required)
- Less suited to consumers wanting fast direct-to-door GLP-1
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out FlyteHealth with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. FlyteHealth remains a solid alternative, especially if you're looking for Members of employers or health plans wanting physician-led obesity care.
Choose FlyteHealth if…
You want Members of employers or health plans wanting physician-led obesity care.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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TrimRx
Best overall value
From $135/mo
Get started →Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →Trimi Health
Budget-conscious shoppers
From $99/mo
Get started →FlyteHealth vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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