Enhance MD vs SkinnyRx
In our scoring, Enhance MD edges ahead overall (8.2 vs 7.6 out of 10), and SkinnyRx costs less for compounded semaglutide (about $753 a year less).
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Key differences
- Price
- SkinnyRx $149.25/mo vs Enhance MD $212/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $753 a year less with SkinnyRx)
- Coverage
- Enhance MD 39 states (SkinnyRx doesn't publish a state list)
- Included
- Enhance MD: medication, clinician visits, labs; SkinnyRx: medication, clinician visits, shipping
- Safety
- FDA warning letters on record: Enhance MD none, SkinnyRx 1
Enhance MD
Affiliate partnerBest for lab-monitored compounded GLP-1 with mandatory video visit
semaglutide
$212
$112 first month
Our score 8.2/10
SkinnyRx
Affiliate partnerBest for compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
semaglutide
$149.25
Our score 7.6/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Enhance MD
SkinnyRx
Price
Semaglutide / month
$212/mo
$112 first month
Better on this row: $149.25/mo
Semaglutide / year (modeled)
$2,544
Better on this row: $1,791
Tirzepatide / month
Better on this row: $169/mo
$224.25/mo
Tirzepatide / year (modeled)
Better on this row: $2,028
$2,691
Oral semaglutide / month
Not listed
$199/mo
Brand Wegovy / Ozempic / month
Not listed
$1,400/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,400/mo
Coverage
State availability
39 states
List not published
Oral option listed
Not listed
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, labs
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Plan quoted after intake; a price is published
Lab work
Required
Not disclosed
Video visit
Required
Not disclosed
Cancel anytime
Yes
Not disclosed
Minimum commitment
None
Not disclosed
Refunds
Not disclosed
90-day money-back guarantee
FDA warning letters
Better on this row: None on record
1 warning letter
Provider facts checked
August 2026
August 2026
Every dose and plan: Enhance MD · SkinnyRx
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Enhance MD if…
- Publishes its full state list (39 states)
- No FDA warning letters on record (SkinnyRx has 1)
- Baseline and ongoing metabolic labs (CMP, lipids, TSH, HbA1c) at Quest every 6 months — rare for compounded GLP-1
What to weigh up
- About $753 a year more than SkinnyRx for compounded semaglutide
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
Choose SkinnyRx if…
- About $753 a year less than Enhance MD for compounded semaglutide at standing prices
- Lists oral compounded semaglutide, brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which Enhance MD doesn't price
- Licensed US clinicians on every prescription
What to weigh up
- 1 FDA warning letter on record
- No published state list; confirm yours at signup
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Enhance MD
8.2/10
SkinnyRx
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo + membership
Get started →From $219/mo
Get started →Enhance MD vs SkinnyRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.