Direct Meds vs MadeMed
In our scoring, MadeMed edges ahead overall (7.4 vs 6.4 out of 10), and MadeMed costs less for compounded semaglutide (about $696 a year less).
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Key differences
- Price
- MadeMed $239/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $696 a year less with MadeMed)
- Included
- Direct Meds: medication, clinician visits, shipping; MadeMed: not stated
- Safety
- FDA warning letters on record: Direct Meds 1, MadeMed none
Direct Meds
Affiliate partnerLegitScript Certified
semaglutide
$297
Our score 6.4/10
MadeMed
Affiliate partnerBest for compounded GLP-1 in both injection and oral forms
semaglutide
$239
Our score 7.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
MadeMed
Price
Semaglutide / month
$297/mo
Better on this row: $239/mo
Semaglutide / year (modeled)
$3,564
Better on this row: $2,868
Tirzepatide / month
$399/mo
$399/mo
Tirzepatide / year (modeled)
$4,788
$4,788
Oral semaglutide / month
$249/mo
Better on this row: $219/mo
Oral semaglutide / year (modeled)
$2,988
Better on this row: $2,628
Oral tirzepatide / month
$299/mo
$299/mo
Oral tirzepatide / year (modeled)
$3,588
$3,588
Coverage
Oral option listed
Yes
Yes
Included in the price
Medication, clinician visits, shipping
Not disclosed
Terms & safety
Price shown
Before intake
Before intake
Lab work
Not disclosed
Not required
Video visit
Not disclosed
Not required
Cancel anytime
No
Not disclosed
Minimum commitment
3-month prepay
Not disclosed
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · MadeMed
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
- Named 503A pharmacy partners: CraftedRx (MO) and ChemistryRx (PA)
What to weigh up
- 1 FDA warning letter on record
- About $696 a year more than MadeMed for compounded semaglutide
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
Choose MadeMed if…
- About $696 a year less than Direct Meds for compounded semaglutide at standing prices
- No FDA warning letters on record (Direct Meds has 1)
- LegitScript certification badge on the homepage
What to weigh up
- Pricing not shown publicly — gated behind product pages or checkout
- Pharmacy partner not named
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
MadeMed
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Read full review →From $169/mo
Get started →GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo
Get started →Direct Meds vs MadeMed: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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