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Amazon One Medical vs Synergy Rx

In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.7 out of 10), and Amazon One Medical costs less for brand-name Wegovy / Ozempic (about $3,401 a year less; one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost).

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By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed

Key differences

Price
Amazon One Medical $199/mo vs Synergy Rx $499/mo for brand-name Wegovy / Ozempic (standing prices, no prepay or separate membership listed · about $3,401 a year less with Amazon One Medical · one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
Coverage
Both serve the same 50 states
Included
Amazon One Medical: clinician visits, shipping (not included: medication, labs); Synergy Rx: medication, clinician visits, shipping

How we compare providers

Amazon One Medical logo

Amazon One Medical

Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery

Brand-name Wegovy / Ozempic

$199/mo

billed every 4 weeks

Our score 8.5/10

Synergy Rx logo

Synergy Rx

Best for broadest drug catalog in the Lion MD white-label cluster

semaglutide

$199/mo

Our score 7.7/10

We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.

Costs & coverage

Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.

Amazon One Medical

Synergy Rx

Price

Brand Wegovy / Ozempic / month

Better on this row: $199/mo

billed every 4 weeks

$499/mo

Brand Wegovy / Ozempic / year (modeled)

Better on this row: $2,587

13 charges

$5,988

Brand Zepbound / Mounjaro / month

Better on this row: $299/mo

billed every 4 weeks

$947/mo

Brand Zepbound / Mounjaro / year (modeled)

Better on this row: $3,887

13 charges

$11,364

Semaglutide / month

Not listed

$199/mo

Tirzepatide / month

Not listed

$349/mo

Oral semaglutide / month

Not listed

$299/mo

Oral tirzepatide / month

Not listed

$399/mo

Brand Wegovy pill / Rybelsus / month

$149/mo

Not listed

Brand Foundayo / month

$149/mo

Not listed

Coverage

State availability

50 states

50 states

Oral option listed

Yes

Yes

Brand-name access listed

Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo

Wegovy / Ozempic, Zepbound / Mounjaro

Included in the price

Clinician visits, shipping

Not included: medication, labs

Medication, clinician visits, shipping

Terms & safety

Price shown

Before intake

Before intake

Lab work

Required

Not disclosed

Refunds

Not disclosed

Non-refundable, all sales final

FDA warning letters

None on record

None on record

Provider facts checked

October 2026

August 2026

Every dose and plan: Amazon One Medical · Synergy Rx

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Which fits your priorities?

Only the points where these two differ, from the table above and each provider’s record.

Amazon One Medical logo

Choose Amazon One Medical if…

  • About $3,401 a year less than Synergy Rx for brand-name Wegovy / Ozempic at standing prices (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
  • Lists brand-name Wegovy pill / Rybelsus and brand-name Foundayo, which Synergy Rx doesn't price
  • Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible

What to weigh up

  • Price doesn't include medication
  • Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Synergy Rx logo

Choose Synergy Rx if…

  • Lists compounded semaglutide, compounded tirzepatide and oral compounded semaglutide, which Amazon One Medical doesn't price
  • Price includes medication; Amazon One Medical's doesn't
  • Broad catalog: compounded sema/tirz in injection and oral dissolving tablet, plus brand Ozempic, Wegovy, and Mounjaro

What to weigh up

  • About $3,401 a year more than Amazon One Medical for brand-name Wegovy / Ozempic (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
  • Same clinician network and pharmacies as Breeze Meds and Care Bare Rx — three brands on one underlying operation

Explore the scoring factors

Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.

Amazon One Medical

8.5/10

Overall

Synergy Rx

7.7/10

Value25%

8.5A
vs
B
7.0

Effectiveness25%

8.5A
vs
B
8.5

User Experience15%

8.0A
vs
B
7.5

Trust & Safety15%

8.8A
vs
B
7.8

Accessibility10%

9.5A
vs
B
8.5

Support10%

8.0A
vs
B
6.9

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Amazon One Medical vs Synergy Rx: FAQ

For brand-name Wegovy / Ozempic, Amazon One Medical costs less: about $3,401 less a year at the standing price, with no prepay or separate membership listed (not a first-month promo); one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost. See Costs & coverage above for each medication side by side.
Amazon One Medical scores higher overall at 8.5/10 versus 7.7/10, and is particularly strong for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery. That said, Synergy Rx is a better fit if you want broadest drug catalog in the Lion MD white-label cluster.
Neither Amazon One Medical nor Synergy Rx is currently an affiliate partner, so we earn no commission from either. We rank all providers editorially using the same six-dimension framework and disclose any commercial relationships.
Amazon One Medical: $199 (billed every 4 weeks, 13 charges a year), about $2,587 a year. Synergy Rx: $499, about $5,988 a year. Amazon One Medical costs about $3,401 less a year at these prices.
Both publish the same list (50 states), so where you live won't decide between them.
Amazon One Medical doesn't state its cancellation terms. Synergy Rx doesn't state its cancellation terms. Check the provider's own terms before you buy.

Key terms, explained

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Continue exploring Amazon One Medical and Synergy Rx head-to-heads in the same category.

Or see the full category ranking.

Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.