1st Optimal vs SkinnyRx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
1st Optimal and SkinnyRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, SkinnyRx starts at $149.25/mo, and SkinnyRx edges ahead overall (7.6 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
SkinnyRx
'As low as $149.25/mo*' — plan-length/promo dependent (matches the sitewide '25% lower prices' promo, $199 x 0.75); standard single-month rate not published pre-intake. Microdose available; free overnight shipping.
'As low as $199/mo*' on /products/semaglutide-oral; once-daily.
'As low as $249/mo*' on /products/semaglutide-tablets.
'As low as $224.25/mo*' and 'Starting at $224.25/mo with free overnight shipping'; microdose available; once-weekly.
'As low as $224.25/mo*' on /products/tirzepatide-tablets; once-daily.
'$1,400/mo*' — '*Price shown applies to Monthly plan paid upfront or with buy now, pay later programs.' 'No membership fees. Same price at every dose.'
'$1,400/mo*' on /products/wegovy-injectable. Wegovy PILL is listed 'Unavailable' ('available via SkinnyRx Membership', fee not published).
'$1,400/mo*' on /products/mounjaro.
'$1,400/mo*' on /products/zepbound. Foundayo (orforglipron) pill also listed but 'Unavailable' — price not published.
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What’s included
1st Optimal
Inclusions not disclosed.
SkinnyRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
SkinnyRx
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | SkinnyRx |
|---|---|---|
| Starting Price | — | $149.25/mo |
| Features | ✓8 features | 3 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About SkinnyRx
Telehealth weight-loss provider offering compounded semaglutide and tirzepatide (injectable, with a microdosing option) prescribed by licensed US clinicians, with the consult and free overnight shipping bundled into a monthly cash price.
Read our full SkinnyRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
SkinnyRx
What we like
- Both semaglutide and tirzepatide available
- Compounded GLP-1 access
- Tiered monthly pricing starting at $199/month
- Licensed US clinicians on every prescription
- Discreet shipping included; cancel anytime
Watch-outs
- Limited public information on program details
- States_available not publicly disclosed — gated behind signup intake
Our Verdict
SkinnyRx edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for mainstream telehealth GLP-1 access. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose SkinnyRx if…
You want mainstream telehealth GLP-1 access and a starting price around $149.25/mo.
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RNK Health
Compounded GLP-1 alongside NAD+, peptide and longevity add-ons
From $197/mo
Get started →Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →1st Optimal vs SkinnyRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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