1st Optimal vs ShapeIn Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
ShapeIn Rx
Best for: shoppers who specifically want compounded liraglutide as a daily option
Visit ShapeIn Rx →1st Optimal and ShapeIn Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, ShapeIn Rx starts at $149/mo, and 1st Optimal edges ahead overall (6.7 vs 6.4 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
ShapeIn Rx
Advertised as Starting from $199/month. Homepage shows a struck $199 next to $149, but the $149 figure is attached to the liraglutide product.
Advertised as Starting from $149/month. Liraglutide is a daily rather than weekly injection. The drug field is omitted because liraglutide is not in the schema's drug enum.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
ShapeIn Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
ShapeIn Rx
6.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | ShapeIn Rx |
|---|---|---|
| Starting Price | — | $149/mo |
| Features | ✓8 features | 5 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About ShapeIn Rx
Phoenix-based telehealth from WellHealth LLC selling compounded semaglutide with B12 and daily compounded liraglutide, with telemedicine limited to states where its providers are licensed.
Read our full ShapeIn Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
ShapeIn Rx
What we like
- One of the few telehealth providers offering compounded liraglutide as a daily alternative to weekly injections
- Semaglutide is compounded with B12, and the combination is stated plainly
- Publishes a street address and a staffed phone line with hours
- States openly that telemedicine is limited to jurisdictions where its providers are licensed, rather than claiming all 50
- LegitScript certification verified against the issued seal, not just the badge
Watch-outs
- Advertises Trusted by 150k Americans and Excellent 4.8 with 150k happy customers, and neither figure is attributable to a verifiable review profile
- No state list is published, only a statement that coverage is limited and a note that partner pharmacies may operate in all 50 states
- The struck-through $199 next to $149 on the homepage reads as a discount but the two prices are different medications
- Claims No Hidden Fees and No Monthly Membership while the Terms state subscriptions automatically renew
- No compounding pharmacy is named, only US-Certified Pharmacy
Our Verdict
1st Optimal edges out ShapeIn Rx with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. ShapeIn Rx remains a solid alternative, especially if you're looking for shoppers who specifically want compounded liraglutide as a daily option.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose ShapeIn Rx if…
You want shoppers who specifically want compounded liraglutide as a daily option and a starting price around $149/mo.
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Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →YourEra
$99 first-month entry pricing on compounded GLP-1s
From $99/mo
Get started →1st Optimal vs ShapeIn Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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