1st Optimal vs RxPros
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
1st Optimal and RxPros are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $99.99/mo, and RxPros edges ahead overall (7.7 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
RxPros
Lowest tier, requires annual prepay; 3-month shipments. All doses same price; includes doctor visit + overnight shipping.
Lowest tier, requires annual prepay; 3-month shipments. All doses same price; includes doctor visit + shipping.
First-month introductory discount for new patients, or paid quarterly. 'Now only $149' banner price also shown.
First-month introductory discount for new patients, or paid quarterly. 'Now only $249' banner price also shown.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
RxPros
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
RxPros
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | RxPros |
|---|---|---|
| Starting Price | ✓$99/mo | $99.99/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About RxPros
RxPros (rxpros.com) is a Wyoming-incorporated compounded GLP-1 telehealth platform (RxPros LLC, 1309 Coffeen Ave Ste 15880, Sheridan, WY 82801). LegitScript Certified. Compounded semaglutide $99.99/month and compounded tirzepatide $144.97/month at the introductory + paid-annually tier. Includes the doctor visit, medication, and overnight cold shipping. Add-on options for Zofran (anti-nausea) and B12.
Read our full RxPros review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
RxPros
What we like
- $99.99/month compounded semaglutide — among the cheapest in the US compounded telehealth market
- $144.97/month compounded tirzepatide — at the lower end of the compounded tirzepatide range
- LegitScript Certified
- Named legal entity (RxPros LLC) with a physical Wyoming address
- Overnight cold-packed shipping disclosed — important for GLP-1 cold-chain integrity
- Add-on Zofran (anti-nausea) and B12 available for managing GI side effects during titration
- Flat pricing across all doses ('Same Price for ALL Dosages, no membership or hidden fees'); 3-month supply shipments
Watch-outs
- Per-state availability not listed — verify your state ships before committing
- Specific 503A pharmacy partners not named
- Lab work not included as standard
- LegitScript certification number not displayed (seal only)
- Lowest headline prices ($99.99 sema / $144.97 tirz) require annual prepay; intro-first-month/quarterly tier is $134.99 sema / $224.99 tirz
Our Verdict
RxPros edges out 1st Optimal with a higher overall score of 7.7/10 and is particularly strong for lowest annual-prepay compounded GLP-1 monthly rate. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose RxPros if…
You want lowest annual-prepay compounded GLP-1 monthly rate and a starting price around $99.99/mo.
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Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →Try Ageless
Lowest-tier compounded GLP-1 in injection, troche and sublingual forms
From $119/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $88/mo
Get started →1st Optimal vs RxPros: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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