1st Optimal vs Revive Meds
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Revive Meds
Best for: compounded GLP-1 with B12 — prepay multi-month for the lowest cost
Visit Revive Meds →1st Optimal and Revive Meds are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $369/mo, and Revive Meds edges ahead overall (7.0 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
Revive Meds
Semaglutide + B12 (cyanocobalamin) injection. Month-to-month $369; multi-month prepay lowers it to $252/mo (3-mo), $216/mo (6-mo), $202/mo (12-mo). Free shipping; no subscription.
Tirzepatide + B12 (cyanocobalamin) injection. Month-to-month $459; multi-month prepay lowers it to $342/mo (3-mo), $306/mo (6-mo), $300/mo (12-mo). Free shipping; no subscription.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Revive Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Revive Meds
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Revive Meds |
|---|---|---|
| Starting Price | ✓$99/mo | $369/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Revive Meds
Revive Meds (revive-meds.com, Revive Health Therapy) is a nationwide GLP-1 and longevity telehealth service that sells compounded semaglutide and dual-agonist tirzepatide, each combined with vitamin B12 (cyanocobalamin), on a pay-per-order basis with no subscription or sign-up fees. Month-to-month pricing is $369 for semaglutide and $459 for tirzepatide, with lower effective rates on 3- to 12-month prepay. Every order ships free. It serves all 50 states, is HSA/FSA eligible, and fulfills through named 503A compounding pharmacies.
Read our full Revive Meds review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Revive Meds
What we like
- Offers both compounded semaglutide and dual-agonist tirzepatide, each combined with vitamin B12 (cyanocobalamin) in a single injection
- Pay-per-order model with no subscription, sign-up fees, or long-term commitment, and free shipping on every order
- Names its six 503A compounding pharmacies and two prescribing physicians, which is unusually transparent on fulfillment
- Available in all 50 states and HSA/FSA eligible through a Medical Necessity Letter
- Prepaying 3 to 12 months cuts the effective cost to as low as $202/mo (semaglutide) or $300/mo (tirzepatide)
Watch-outs
- Month-to-month pricing is steep: $369/mo semaglutide and $459/mo tirzepatide unless you prepay several months
- No public price list; pricing appears only after you complete a full health intake and create an account
- Not LegitScript-certified (no seal displayed on the site)
- Compounded semaglutide and tirzepatide are not FDA-approved finished products
Our Verdict
Revive Meds edges out 1st Optimal with a higher overall score of 7.0/10 and is particularly strong for compounded GLP-1 with B12 — prepay multi-month for the lowest cost. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose Revive Meds if…
You want compounded GLP-1 with B12 — prepay multi-month for the lowest cost and a starting price around $369/mo.
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MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $199/mo
Get started →1st Optimal vs Revive Meds: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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