1st Optimal vs Rejuve Meds
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Rejuve Meds
Best for: transparent, low-cost compounded GLP-1, no membership, HSA/FSA eligible
Visit Rejuve Meds →1st Optimal and Rejuve Meds are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Rejuve Meds starts at $165/mo, and Rejuve Meds edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Rejuve Meds
$165/mo; intro from $85 first month; $120 summer discount auto-applied; free shipping
Dual-action GLP-1/GIP compounded formulation; $265/mo
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Rejuve Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Rejuve Meds
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Rejuve Meds |
|---|---|---|
| Starting Price | — | $165/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Rejuve Meds
Rejuve Meds (Rejuve, Inc.) is a GLP-1 weight-loss telehealth service offering doctor-guided compounded semaglutide at $165/mo and dual-action compounded tirzepatide (GLP-1/GIP) at $265/mo, with no membership fees, free shipping, and HSA/FSA eligibility. Intro pricing starts around $85 for the first month. Medication is fulfilled through its "Rejuve Meds Pharmacy Network"; the individual pharmacies, prescribing medical group, and state-availability list are not named on the marketing site.
Read our full Rejuve Meds review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Rejuve Meds
What we like
- Transparent published pricing: compounded semaglutide $165/mo, tirzepatide $265/mo
- No membership fees — everything is included; free shipping
- HSA/FSA eligible; intro pricing from $85 for the first month
- Doctor-guided programs with personalized care
- Names a "Rejuve Meds Pharmacy Network" for fulfillment
Watch-outs
- Individual compounding pharmacies not named (only a "pharmacy network")
- Prescribing medical group not named
- States of operation not published
- Not LegitScript-certified (no certification displayed)
Our Verdict
Rejuve Meds edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for transparent, low-cost compounded GLP-1, no membership, HSA/FSA eligible. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Rejuve Meds if…
You want transparent, low-cost compounded GLP-1, no membership, HSA/FSA eligible and a starting price around $165/mo.
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GobyMeds
Budget-conscious shoppers
From $93/mo
Get started →Direct Meds
Listed for disclosure only — see its FDA warning and BBB complaints first
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →1st Optimal vs Rejuve Meds: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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