1st Optimal vs PrescribedRX
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
PrescribedRX
Best for: people who want compounded GLP-1 weight loss inside a broader men's and women's telehealth brand
Visit PrescribedRX →1st Optimal and PrescribedRX are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, PrescribedRX starts at $189/mo, and PrescribedRX edges ahead overall (6.8 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
PrescribedRX
Monthly plan $189/mo; as low as $176/mo on the 3-month plan ($526)
Monthly plan $276/mo; as low as $233/mo on the 3-month plan ($697)
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
PrescribedRX
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
PrescribedRX
6.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | PrescribedRX |
|---|---|---|
| Starting Price | — | $189/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About PrescribedRX
PrescribedRX is a multi-condition telehealth brand (TRT, longevity, hair loss, sexual health and weight loss) that prescribes compounded GLP-1 injectables for weight loss: semaglutide at $189/month and tirzepatide at $276/month, dropping to $176 and $233/month on a 3-month plan. Care is delivered online with licensed US-provider oversight and monthly home delivery, and the site is bilingual (English/Spanish) with Florida/Palm Beach-focused offers. It runs an in-house affiliate program but does not name its compounding pharmacies or publish the states it serves.
Read our full PrescribedRX review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
PrescribedRX
What we like
- Compounded semaglutide ($189/mo) and tirzepatide ($276/mo) injectables, with lower per-month pricing on the 3-month plans ($176 and $233/mo)
- Clear, upfront plan pages showing monthly and multi-month pricing with no surprise fees
- Care from licensed US providers with monthly home delivery and ongoing dose support
- Bilingual English/Spanish site and a broader telehealth menu (TRT, longevity, hair, sexual health) for people who want more than weight loss
Watch-outs
- Doesn't publish the states it serves — you only learn eligibility after starting the intake
- Compounding pharmacies aren't named on the site
- Mid-range pricing — cheaper compounded GLP-1 options exist and the 3-month discount is modest
- Compounded semaglutide and tirzepatide injectables only — no brand-name or oral options
- Self-hosted affiliate program (not a vetted network); Florida/Palm Beach framing suggests a regional lean
Our Verdict
PrescribedRX edges out 1st Optimal with a higher overall score of 6.8/10 and is particularly strong for people who want compounded GLP-1 weight loss inside a broader men's and women's telehealth brand. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose PrescribedRX if…
You want people who want compounded GLP-1 weight loss inside a broader men's and women's telehealth brand and a starting price around $189/mo.
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MEDVi
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From $99/mo
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Compounded GLP-1 paired with a muscle-preservation supplement stack
From $179/mo
Get started →DudeMeds
Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →1st Optimal vs PrescribedRX: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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