1st Optimal vs PeterMD
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
PeterMD
Best for: men seeking flat-priced compounded GLP-1 access alongside TRT or peptide therapy
Visit PeterMD →1st Optimal and PeterMD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, PeterMD starts at $105/mo, and PeterMD edges ahead overall (7.5 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
PeterMD
Flat $105/mo; includes GLP1 injections, supplies, shipping, physician consults, optimization software
Semaglutide combined with MIC/B12 injections
Semaglutide combined with phentermine and B12
Get Started for $149, then $249/mo billed quarterly; struck regular price $315
60mg plan; $149 start then $249/mo billed quarterly; struck regular price $628
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What’s included
1st Optimal
Inclusions not disclosed.
PeterMD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
PeterMD
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | PeterMD |
|---|---|---|
| Starting Price | — | $105/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 42 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About PeterMD
PeterMD is a men's telehealth platform offering compounded GLP-1 weight loss medications (semaglutide and tirzepatide, often with B12). Also covers TRT, peptide therapy, sexual health, and anti-aging treatments. Transparent monthly pricing with no insurance required.
Read our full PeterMD review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
PeterMD
What we like
- Flat pricing across semaglutide dose tiers (0.25mg through 2.4mg)
- Both semaglutide and tirzepatide available
- Month-to-month cancellation via patient portal, no cancellation fee
- Covers men's-health adjacencies (TRT, peptides, ED, anti-aging) in one account
- Compounded semaglutide at a flat $105/mo billed monthly — among the lowest in the category
Watch-outs
- Not available in 8 states (AL, AR, CA, HI, ID, MI, NC, TX)
- Men's-only branding — will not appeal to women seeking GLP-1 access
- Pharmacy partner and named clinicians not publicly disclosed
- Tirzepatide is billed quarterly at $249/mo — you commit to a ~3-month charge upfront
Our Verdict
PeterMD edges out 1st Optimal with a higher overall score of 7.5/10 and is particularly strong for men seeking flat-priced compounded GLP-1 access alongside TRT or peptide therapy. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose PeterMD if…
You want men seeking flat-priced compounded GLP-1 access alongside TRT or peptide therapy and a starting price around $105/mo.
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Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $159/mo
Get started →1st Optimal vs PeterMD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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