1st Optimal vs Pepti
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Pepti
Best for: the lowest all-in monthly price we have verified on compounded semaglutide, labs included
Visit Pepti →1st Optimal and Pepti are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Pepti starts at $99/mo, and Pepti edges ahead overall (7.9 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Pepti
All-in monthly subscription covering medication, physician care, labs and shipping. A one-time non-subscription vial is $124.
All-in monthly subscription. A one-time non-subscription vial is $249.
Oral semaglutide, priced above the injectable.
Oral tirzepatide, priced above the injectable.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Pepti
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Included
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Pepti
7.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Pepti |
|---|---|---|
| Starting Price | — | $99/mo |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | 36 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Pepti
Pepti is a Delaware-registered telehealth platform selling doctor-prescribed compounded peptides and GLP-1s across 36 states. Injectable semaglutide is $99 a month all-in and tirzepatide $199, each covering medication, physician review, baseline labs, refill management and shipping in a single flat price that does not rise with dose. The catalogue runs to more than 120 products across weight loss, hormones and TRT, recovery, cognitive and skin categories, plus at-home bloodwork. Pepti is a platform, not a prescriber, and does not bill insurance.
Read our full Pepti review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Pepti
What we like
- At $99/mo all-in, injectable semaglutide is among the cheapest verified prices in our catalogue.
- States plainly that all doses cost one flat monthly price, so titrating up never raises the bill.
- Publishes a page for each of the 36 states it serves, and the page count matches its claim exactly.
- Names the reviewing physician, Dr. Gene Lee MD, and discloses pepti LLC as the Delaware operating entity.
Watch-outs
- The homepage shows an "FDA Cleared" badge beside peptide therapy, though product pages correctly say compounded drugs are not FDA-approved.
- Neither the 503A nor the 503B compounding pharmacy is named, so you cannot check who dispenses.
- The listed address, a Newark Delaware suite, is a shared registered-agent address rather than a clinical office.
- Cash-pay only with no insurance billing, and the oral formulations jump to $249 and $399 a month.
Our Verdict
Pepti edges out 1st Optimal with a higher overall score of 7.9/10 and is particularly strong for the lowest all-in monthly price we have verified on compounded semaglutide, labs included. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Pepti if…
You want the lowest all-in monthly price we have verified on compounded semaglutide, labs included and a starting price around $99/mo.
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Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
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Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →1st Optimal vs Pepti: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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