1st Optimal vs PepHaūs
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programPepHaūs
Best for shoppers who want all-inclusive compounded GLP-1 pricing shipped nationwideStarting at $152/mo
Side-by-Side Comparison
| Feature | 1st Optimal | PepHaūs |
|---|---|---|
| Overall Score | 6.7/10 | ✓7.6/10 |
| Starting Price | — | $152/mo |
| Editorial Rating | 3.4 ★ /5 | ✓3.8 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
PepHaūs
What we like
- All-inclusive pricing — medication, medical visit, and shipping bundled into one cost
- Compounded semaglutide from $152/mo (quarterly) and tirzepatide from $246/mo
- LegitScript-certified (#50233613); 503A-compounded medication
- Ships to all 50 states from U.S.-licensed 503A pharmacies
- Quick online intake with 24-hour provider review
Watch-outs
- Compounding pharmacy partners aren't named on the marketing site
- Pricing is customized per patient, so your final cost can vary from the advertised 'from' rates
- No published individual clinician or medical-director names
- Newer multi-vertical brand (also NAD+, sermorelin, glutathione) with a limited weight-loss track record
Our Verdict
PepHaūs edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for shoppers who want all-inclusive compounded GLP-1 pricing shipped nationwide. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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