1st Optimal vs PepHaūs
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
PepHaūs
Best for: shoppers who want all-inclusive compounded GLP-1 pricing shipped nationwide
Visit PepHaūs →1st Optimal and PepHaūs are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, PepHaūs starts at $152/mo, and PepHaūs edges ahead overall (7.6 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
PepHaūs
From $152/mo on quarterly plan ($179/mo otherwise)
From $246/mo
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
PepHaūs
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
PepHaūs
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | PepHaūs |
|---|---|---|
| Starting Price | — | $152/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About PepHaūs
PepHaūs is a telehealth pharmacy offering compounded GLP-1 weight-loss treatment — semaglutide from $152/mo and tirzepatide from $246/mo — prescribed by U.S.-licensed providers and shipped from 503A compounding pharmacies. Its pitch is all-inclusive pricing: the medication, medical visit, and shipping are bundled into one cost, with an extra 15% off on quarterly plans. It also offers NAD+, sermorelin, and glutathione alongside weight loss.
Read our full PepHaūs review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
PepHaūs
What we like
- All-inclusive pricing — medication, medical visit, and shipping bundled into one cost
- Compounded semaglutide from $152/mo (quarterly) and tirzepatide from $246/mo
- LegitScript-certified (#50233613); 503A-compounded medication
- Ships to all 50 states from U.S.-licensed 503A pharmacies
- Quick online intake with 24-hour provider review
Watch-outs
- Compounding pharmacy partners aren't named on the marketing site
- Pricing is customized per patient, so your final cost can vary from the advertised 'from' rates
- No published individual clinician or medical-director names
- Newer multi-vertical brand (also NAD+, sermorelin, glutathione) with a limited weight-loss track record
Our Verdict
PepHaūs edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for shoppers who want all-inclusive compounded GLP-1 pricing shipped nationwide. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose PepHaūs if…
You want shoppers who want all-inclusive compounded GLP-1 pricing shipped nationwide and a starting price around $152/mo.
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Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →1st Optimal vs PepHaūs: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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