1st Optimal vs Pallas Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Pallas Health
Best for: the most complete public disclosure of pharmacies and prescribing physicians we have found
Visit Pallas Health →1st Optimal and Pallas Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Pallas Health starts at $199/mo, and Pallas Health edges ahead overall (8.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Pallas Health
$139 for the first month, then $597 every 12 weeks, which Pallas advertises as a $199/mo average. Same price at every dose. Provider care and check-ins included.
$179 for the first month, then $897 every 12 weeks, advertised as a $299/mo average. Same price at every dose.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Pallas Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Pallas Health
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Pallas Health |
|---|---|---|
| Starting Price | — | $199/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 51 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Pallas Health
Pallas Health is a telehealth platform operated by Brentmoor, Inc. offering compounded semaglutide and tirzepatide alongside brand-name Wegovy, Ozempic, Zepbound and Mounjaro. Compounded plans average $199 and $299 a month with provider care, check-ins and messaging included and no separate membership fee, and the price stays the same at every dose. Its clinical disclosures page is unusually complete: two named advising physicians with verifiable NPIs, the clinical partner Lion MD, six named partner pharmacies, and coverage in all 50 states plus DC.
Read our full Pallas Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Pallas Health
What we like
- Names six partner pharmacies with phone numbers and websites, the most complete pharmacy disclosure we have recorded.
- Publishes two advising physicians with NPI numbers you can verify yourself in the federal NPPES registry.
- Price stays the same at every dose, and provider care, check-ins and messaging are included with no membership fee.
- Offers brand-name Wegovy, Ozempic, Zepbound and Mounjaro alongside compounded options, and serves all 50 states plus DC.
Watch-outs
- Billed $597 every 12 weeks, not monthly; at 4.33 cycles a year the true cost is about $216/mo, above the $199 advertised.
- The homepage claims "200,000+ patients" while the clinical page describes a July 2026 launch and existing waitlist patients.
- Cancelling after a payment deducts third-party processing costs plus a $5 fee per refunded payment.
- In states requiring a live video visit a $60 deposit is taken at checkout, and it may be retained if you abandon the intake.
Our Verdict
Pallas Health edges out 1st Optimal with a higher overall score of 8.1/10 and is particularly strong for the most complete public disclosure of pharmacies and prescribing physicians we have found. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Pallas Health if…
You want the most complete public disclosure of pharmacies and prescribing physicians we have found and a starting price around $199/mo.
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Oral-lozenge compounded GLP-1 access
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Mainstream telehealth GLP-1 access
From $146/mo
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Best overall value
From $135/mo
Get started →1st Optimal vs Pallas Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.