1st Optimal vs OzielRx
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
OzielRx
Best for: the cheapest flat-rate compounded GLP-1 with no membership fee
Visit OzielRx →1st Optimal and OzielRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, OzielRx starts lower at $79/mo versus $99/mo, and OzielRx edges ahead overall (8.0 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
OzielRx
Verbatim: 'Semaglutide is $79 for one month ($207 for three)'. The $69/mo figure is the 3-month plan, paid as a single $207 charge up front -- not a lower monthly bill. Shown against a struck-through '$299 retail'. Same price at every dose.
Verbatim: 'Tirzepatide is $129 for one month ($357 for three)'. The $119/mo figure is the 3-month plan, paid as a single $357 charge up front. Shown against a struck-through '$349 retail'. Same price at every dose.
Get alerted when GLP-1 prices drop
Join the GLP-1 price-watch list — we re-verify 480+ providers' prices on their own sites and email you when tracked prices move.
What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
OzielRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
OzielRx
8.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | OzielRx |
|---|---|---|
| Starting Price | $99/mo | ✓$79/mo |
| Features | ✓8 features | 3 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About OzielRx
OzielRx (ozielrx.com) is a telehealth platform operated by OzielRx LLC selling compounded semaglutide and tirzepatide as flat-priced one-month or three-month plans. It charges no membership or consultation fee, holds the same price at every dose, and includes free shipping on every plan.
Read our full OzielRx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
OzielRx
What we like
- Among the cheapest compounded GLP-1 pricing we track — $79 for a month of semaglutide, $129 for tirzepatide
- No membership fee and no consultation fee, stated plainly on the homepage
- Same price at every dose, so titrating up does not raise the bill
- Free shipping on every plan, and the eligibility assessment needs no card
- Full refund if a provider decides treatment is not appropriate, typically within 5 business days
Watch-outs
- Marketed as a one-time purchase where 'nothing renews', but the site's own policy text describes canceling before the next renewal
- The three-month price is a single up-front charge, not a lower monthly bill
- Compounding pharmacies are not named anywhere on the site
- State availability is not published
Our Verdict
OzielRx edges out 1st Optimal with a higher overall score of 8.0/10 and is particularly strong for the cheapest flat-rate compounded GLP-1 with no membership fee. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose OzielRx if…
You want the cheapest flat-rate compounded GLP-1 with no membership fee and a starting price around $79/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →TrimRx
Best overall value
From $149/mo
Get started →Sprout Health
LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →1st Optimal vs OzielRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and OzielRx head-to-heads in the same category.
- 1st Optimal vs Amazon One Medical
- 1st Optimal vs Vytora Health
- 1st Optimal vs Collective
- OzielRx vs CoreAge Rx
- OzielRx vs EverSlim
- OzielRx vs Found
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.