1st Optimal vs Oak
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programOak
Best for compounded semaglutide and tirzepatide at a flat monthly priceStarting at $80/mo
Side-by-Side Comparison
| Feature | 1st Optimal | Oak |
|---|---|---|
| Overall Score | 6.7/10 | ✓7.6/10 |
| Starting Price | — | $80/mo |
| Editorial Rating | 3.4 ★ /5 | ✓3.8 ★ /5 |
| Features | ✓8 features | 4 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
Pros
- ✓Offers both semaglutide and tirzepatide with injectable and oral formats
- ✓Functional-medicine approach with at-home labs and blood-work interpretation
- ✓Unlimited coaching and ongoing support included
- ✓No long-term contracts
- ✓Board-certified doctors and nurse practitioners referenced
Cons
- ✗No public monthly pricing disclosed
- ✗No published state availability list
- ✗Compounded vs branded sourcing not clarified on site
- ✗Pricing only revealed after quiz or consultation
Oak
Pros
- ✓Both compounded semaglutide ($130/mo) and tirzepatide ($199/mo) on a single platform
- ✓$50 off first month with code OAKNEW50
- ✓LegitScript-certified pharmacy network
- ✓No video call required for initial approval; flat per-month pricing across all dose strengths
Cons
- ✗Pharmacy partners are not publicly named on the marketing site (material gap for YMYL disclosure)
- ✗Operates in 45 states per Terms of Use, but the public state list is gated behind the signup intake
- ✗No brand-name Wegovy / Zepbound / Mounjaro / Ozempic available — compounded only
- ✗Fees are non-refundable per Terms of Use; binding arbitration under Delaware law
Our Verdict
Oak edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for compounded semaglutide and tirzepatide at a flat monthly price. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring 1st Optimal and Oak head-to-heads in the same category.
- 1st Optimal vs CoreAge Rx
- 1st Optimal vs TrimRx
- 1st Optimal vs Amazon One Medical
- Oak vs NovoCare Pharmacy
- Oak vs Vytora Health
- Oak vs Enhance MD
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.