1st Optimal vs Oak
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
1st Optimal and Oak are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Oak starts at $119/mo, and Oak edges ahead overall (8.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Oak
Hero + product card: 'Semaglutide from $119' / 'Most Affordable Semaglutide As low as $119 /mo'. Old code OAKNEW50 no longer on site; a '$200 off — new patient offer' is advertised with no published terms or resulting price (quiz-gated), so promo price is not published. Site is internally inconsistent elsewhere ($133 meta description, $167 compare table, $190 on /weightloss) — hero pricing matches
Hero + product card: 'Tirzepatide from $185' / 'Most Popular Tirzepatide As low as $185 /mo'. Same flat 'One price · All dosages · No subscriptions' model; $200-off new-patient offer advertised without published mechanics — final checkout price quiz-gated, not published.
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What’s included
1st Optimal
Inclusions not disclosed.
Oak
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Oak
8.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Oak |
|---|---|---|
| Starting Price | — | $119/mo |
| Features | ✓8 features | 4 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Oak
Telehealth provider offering compounded GLP-1 medications (semaglutide and tirzepatide) operated by Oak Longevity Holdings Corp. with prescriptions issued through NVP Medical Group, P.A.
Read our full Oak review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Oak
What we like
- Both compounded semaglutide ($119/mo) and tirzepatide ($185/mo) on a single platform
- $200-off new-patient offer advertised — final discounted price is shown after the intake quiz
- LegitScript-certified pharmacy network
- No video call required for initial approval; flat per-month pricing across all dose strengths
Watch-outs
- Pharmacy partners are not publicly named on the marketing site (material gap for YMYL disclosure)
- Operates in 45 states per Terms of Use, but the public state list is gated behind the signup intake
- No brand-name Wegovy / Zepbound / Mounjaro / Ozempic available — compounded only
- Fees are non-refundable per Terms of Use; binding arbitration under Delaware law
Our Verdict
Oak edges out 1st Optimal with a higher overall score of 8.1/10 and is particularly strong for compounded semaglutide and tirzepatide at a flat monthly price. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Oak if…
You want compounded semaglutide and tirzepatide at a flat monthly price and a starting price around $119/mo.
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MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Breeze Meds
Compounded GLP-1 access with named prescribers and 4-pharmacy network
From $169/mo
Get started →1st Optimal vs Oak: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.