1st Optimal vs NuDay Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for Patients wanting GLP-1 therapy within a lab-driven functional-medicine programNuDay Rx
Best for Shoppers wanting both compounded and brand GLP-1 options with coaching and a doctor consultStarting at $249/mo
Side-by-Side Comparison
| Feature | 1st Optimal | NuDay Rx |
|---|---|---|
| Overall Score | 6.7/10 | ✓7.2/10 |
| Starting Price | — | $249/mo |
| Editorial Rating | 3.4 ★ /5 | ✓3.6 ★ /5 |
| Features | 8 features | 8 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
NuDay Rx
What we like
- Wide selection — compounded semaglutide ($249) and tirzepatide ($329), oral tablet options, plus brand GLP-1 (cash pay)
- Includes video coaching and lifestyle support with a licensed-doctor consult
- Full legal suite published (Terms, Privacy, Privacy Practices, Medical Consent)
- Prescription delivered to your door after an online intake and consult
Watch-outs
- Compounded semaglutide ($249) is pricier than some budget competitors
- Compounding pharmacy partner not named
- Not LegitScript-certified (no certification displayed)
- Runs on a shared white-label telehealth platform (CareValidate/careGLP)
Our Verdict
NuDay Rx edges out 1st Optimal with a higher overall score of 7.2/10 and is particularly strong for Shoppers wanting both compounded and brand GLP-1 options with coaching and a doctor consult. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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