Always verify pricing and state availability on the provider's website before signing up.How our reviews work →

1st Optimal vs Neo Soma Healthcare

An in-depth comparison of two leading GLP-1 Providers

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

By Eli Marsden · Founding Editor
Editorially reviewed & fact-checked against primary sources · How we verify contentLast reviewed
1st Optimal logo

1st Optimal

6.7
★★★☆☆3.4/5

Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program

Visit 1st Optimal
VS
Neo Soma Healthcare logo

Neo Soma Healthcare

6.1
★★★☆☆3.1/5

Best for: compounded GLP-1 bundled with sexual health and anti-aging

Visit Neo Soma Healthcare

1st Optimal and Neo Soma Healthcare are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Neo Soma Healthcare starts at $99/mo, and 1st Optimal edges ahead overall (6.7 vs 6.1 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.

Pricing

1st Optimal

Pricing not publicly listed.

Neo Soma Healthcare

All doses (semaglutide first-month promo)Compounded
$99/mo
semaglutide
All doses (semaglutide standard)Compounded
$199/mo
semaglutide
All doses (tirzepatide initial purchase)Compounded
$330/mo
tirzepatide

Get alerted when GLP-1 prices drop

Join the GLP-1 price-watch list — we re-verify 390+ providers' prices on their own sites and email you when tracked prices move.

What’s included

1st Optimal

Inclusions not disclosed.

Neo Soma Healthcare

What the monthly price covers

Medication

Included

Provider visits

Not disclosed

Shipping

Not disclosed

Lab work

Not disclosed

Coaching

Not disclosed

Score breakdown

Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.

1st Optimal

6.7/10

Overall

Neo Soma Healthcare

6.1/10

Value25%

6.5A
vs
B
6.0

Effectiveness25%

7.0A
vs
B
6.0

User Experience15%

6.5A
vs
B
6.0

Trust & Safety15%

6.5A
vs
B
6.3

Accessibility10%

6.5A
vs
B
6.0

Support10%

7.4A
vs
B
6.4

Features & Coverage

Feature1st OptimalNeo Soma Healthcare
Starting Price$99/mo
Features8 features6 features
States AvailableNot disclosedNot disclosed
Compounded✓ Yes
Brand Name
FSA/HSA Accepted
FDA WarningsNoneNone

About 1st Optimal

1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.

Read our full 1st Optimal review →

About Neo Soma Healthcare

Neo Soma Healthcare is a multi-product DTC telehealth platform pairing compounded GLP-1 weight management with sexual-health and anti-aging lines. Its differentiator is that bundled menu plus a quick (under 20 minutes) online intake, unlimited follow-up messaging, and a published FDA compounded-medication disclaimer. Compounded semaglutide runs $99 the first month then $199/mo; compounded tirzepatide is $330 to start.

Read our full Neo Soma Healthcare review →

Pros & Cons

1st Optimal

What we like

  • Offers both semaglutide and tirzepatide with injectable and oral formats
  • Functional-medicine approach with at-home labs and blood-work interpretation
  • Unlimited coaching and ongoing support included
  • No long-term contracts
  • Board-certified doctors and nurse practitioners referenced

Watch-outs

  • No public monthly pricing disclosed
  • No published state availability list
  • Compounded vs branded sourcing not clarified on site
  • Pricing only revealed after quiz or consultation

Neo Soma Healthcare

What we like

  • LegitScript verification badge present
  • Publishes the FDA compounded-medication disclaimer
  • Pricing shown publicly for all 6 product lines
  • Multi-product platform (GLP-1, sexual health, peptide therapies)
  • First-month discount on semaglutide ($99 entry)
  • Quick online intake (under 20 minutes)

Watch-outs

  • Pharmacy partner not named (503A vs 503B unclear)
  • States served not listed — no per-state availability table
  • No named medical director
  • Standard semaglutide pricing ($199/mo) above the cheapest providers ($150–180/mo)
  • Tirzepatide entry pricing ($330) above the cheapest providers (~$200–250/mo)
  • Multi-product platform — less GLP-1-specific depth than single-product specialists

Our Verdict

Winner: 1st Optimal

1st Optimal edges out Neo Soma Healthcare with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. Neo Soma Healthcare remains a solid alternative, especially if you're looking for compounded GLP-1 bundled with sexual health and anti-aging.

Choose 1st Optimal if…

You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.

Choose Neo Soma Healthcare if…

You want compounded GLP-1 bundled with sexual health and anti-aging and a starting price around $99/mo.

Ready to start? Vetted GLP-1 providers

Vetted telehealth providers that prescribe GLP-1 online.

No insurance needed · vetted by our editors

WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more

7.6

SkinnyRx

Mainstream telehealth GLP-1 access

7.3

Sunlight

Compounded GLP-1 with unlimited telehealth visits and free shipping

7.4

MadeMed

Compounded GLP-1 in both injection and oral forms

1st Optimal vs Neo Soma Healthcare: FAQ

Key terms, explained

New to GLP-1s? Tap any term for a quick, plain-English definition.

Continue exploring 1st Optimal and Neo Soma Healthcare head-to-heads in the same category.

Or see the full category ranking.

Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.