1st Optimal vs Mondae
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Mondae
Best for: choosing your own compounding pharmacy from a named list, at one flat price per dose
Visit Mondae →1st Optimal and Mondae are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Mondae starts at $115/mo, and Mondae edges ahead overall (7.7 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Mondae
Same $115 whether the 1-month or 3-month plan is selected; a struck-through $600 is shown as an anchor price.
Same $145 on both the 1-month and 3-month plan.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Mondae
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Mondae
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Mondae |
|---|---|---|
| Starting Price | — | $115/mo |
| Features | ✓8 features | 7 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Mondae
Mondae is a compounded GLP-1 telehealth platform run by Mondae LLC that lets you pick which pharmacy fills your prescription from a named list of six, and holds one price across every dose. Compounded semaglutide is $115 a month and compounded tirzepatide is $145 a month, billed monthly, with the same rate whether you choose the one or three-month plan. It also offers sermorelin, NAD+ and glutathione injections.
Read our full Mondae review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Mondae
What we like
- Lets you choose which of six named pharmacies fills your prescription, which almost no competitor offers
- Discloses the compounding additive (glycine) on the product page, not buried in an FAQ
- One price at every dose: $115 semaglutide and $145 tirzepatide, with no dose-escalation markup
- Prices and the full dose ladder are published before any intake, with no membership fee
- Available in all 50 states through physicians licensed in your state of residence
Watch-outs
- Refunds are explicitly not guaranteed and the Terms state fees are not refundable in whole or in part
- Orders can only be cancelled before the medication is dispensed or shipped
- The homepage advertises prices from $113 while the cheapest GLP-1 plan is actually $115
- A struck-through $600 is displayed next to the $115 price with no explanation of what $600 refers to
- The pharmacy that fills your order may change which additives are included
Our Verdict
Mondae edges out 1st Optimal with a higher overall score of 7.7/10 and is particularly strong for choosing your own compounding pharmacy from a named list, at one flat price per dose. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program.
Choose Mondae if…
You want choosing your own compounding pharmacy from a named list, at one flat price per dose and a starting price around $115/mo.
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Get started →1st Optimal vs Mondae: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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